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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

Fig. 1

Ratio of soluble Aβ aggregate levels to plaque area fully distinguishes non-demented controls with high plaque pathology from patients with dementia of the Alzheimer’s type and comparable plaque burden. Reproduced from Figure 2N of Esparza et al. 2013 [24]. Soluble Aβ aggregate levels expressed as dimer equivalents (pg/ml). Clinical dementia rating (CDR) of 0 indicates absence of dementia and rating of 1 indicates mild/early dementia. ***p = 0.0001, Mann–Whitney U test

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