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Table 2 Utilization of diagnostic procedures to identify biomarkers and average costs of the diagnostic process for the total sample and depending on the subsequently received dementia diagnosis

From: Cost of diagnosing dementia in a German memory clinic

  Total sample (n = 120) Patients who were finally diagnosed with dementiaa (n = 53) Patients who were finally not diagnosed with dementiab (n = 67) p valuec
  n (%) n (%) n (%)  
Utilization of procedures
 Blood test 44 (36.7) 27 (50.9) 17 (25.4) 0.005
 MRI 71 (59.2) 38 (71.7) 33 (49.3) 0.016
 CT 20 (16.7) 14 (26.4) 6 (8.9) 0.014
 CSF 22 (18.3) 11 (20.8) 11 (16.4) 0.637
 PET 7d (5.8) 4d (7.5) 3 (4.5) 0.698
Cost of diagnosis Mean 95CI 95CI+ Mean 95CI 95CI+ Mean 95CI 95CI+  
 Time-related processes (€) 110 105 115 121 114 128 103 96 109 0.002
 Diagnostic procedures (€) 391 320 460 538 421 655 274 199 348 0.001
 Total diagnostic process (€) 501 430 573 659 540 778 376 301 451 0.001
  1. Differences in means were evaluated using two-tailed t tests referring to patients diagnosed with dementia and without dementia diagnosis
  2. MRI magnetic resonance imaging, CT computer tomography, CSF cerebrospinal fluid puncture, PET positron emission tomography, 95CI 95% confidence interval, ICD International Statistical Classification of Diseases and Related Health Problems
  3. aReferring to the following ICD-10 diagnoses: F00.0, F00.1, F01.1, F00.2, F02.0, and F03
  4. bReferring to the following ICD-10 diagnoses: F06.7, F33.1, F34.1, F41.2, F31.1, and F60.3, and other conditions or no hint for cognitive impairment
  5. cDifferences in proportions evaluated using Fischer’s exact test, differences in means evaluated using t tests
  6. dOne patient received florbetaben PET, all others fluorodeoxyglucose PET