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Table 4 Association between baseline characteristics and cognitive categories in the MEMENTO cohort

From: Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

  Cognitive categories  
Isolated cognitive complaint Single-domain aMCI Multi-domain aMCI Single-domain naMCI Multi-domain naMCI P valuea
No. of subjects 370 207 998 392 346  
Female sex, % 65.4 51.2 57.3 66.8 71.7 <0.0001
Age in years, mean (SD) 69.8 (8.0) 68.8 (9.6) 70.9 (9.0) 71.6 (8.0) 72.2 (8.6) <0.0001
Baccalaureate degree or above, % 65.8 58.0 47.3 61.9 55.2 <0.0001
Diabetes, % 4.9 7.3 8.9 5.6 7.8 0.07
Hypertension, % 28.4 34.3 35.4 31.6 37.0 0.08
Dyslipidaemia, % 26.0 26.1 30.5 26.3 25.1 0.19
History of cardiovascular disease, % 9.0 10.7 13.5 11.0 11.9 0.21
Apathy, % 7.1 15.7 22.2 14.3 17.7 <0.0001
Depression, % 27.3 31.1 38.9 27.6 33.4 <0.0001
Anxiety, % 32.1 43.3 46.9 36.9 42.1 <0.0001
Number of limitations in IADL, %
 One 8.3 7.4 10.1 11.2 13.4 0.04
 Two or more 1.7 2.6 3.3 0.8 3.3
SPPB score, mean (SD) 10.9 (0.09) 10.5 (0.13) 10.3 (0.06) 10.7 (0.09) 10.5 (0.10) <0.0001
At least one APOE ε4 allele carried, % 26.0 27.3 33.5 20.9 26.0 0.007
CDR Sum of Boxes, mean (SE) 0.33 (0.03) 0.50 (0.05) 0.85 (0.02) 0.38 (0.03) 0.53 (0.04) <0.0001
MMSE score, mean (SE) 28.7 (0.09) 28.3 (0.12) 27.3 (0.06) 28.5 (0.09) 27.9 (0.10) <0.0001
Verbal fluency, letter P, mean (SE) 24.0 (0.34) 22.9 (0.45) 18.5 (0.21) 22.0 (0.33) 18.7 (0.35) <0.0001
Verbal fluency, animals, mean (SE) 33.7 (0.41) 31.6 (0.55) 25.0 (0.25) 21.3 (0.40) 26.9 (0.41) <0.0001
DMS48, immediate recall, mean (SE) 46.9 (0.18) 43.9 (0.24) 42.5 (0.11) 46.9 (0.17) 46.8 (0.19) <0.0001
Praxis total score, mean (SE) 22.7 (0.08) 22.6 (0.10) 21.5 (0.05) 22.1 (0.07) 21.2 (0.08) <0.0001
TMT A time, seconds, mean(SE) 1.6 (0.04) 1.6 (0.06) 2.3 (0.03) 1.9 (0.4) 2.3 (0.05) <0.0001
TMT B time, seconds, mean (SE) 3.5 (0.21) 3.7 (0.29) 6.4 (0.13) 4.2 (0.21) 5.7 (0.22) <0.0001
FCSRT, total immediate free recall, mean (SE) 30.7 (0.36) 25.7 (0.48) 21.9 (0.22) 29.8 (0.34) 28.0 (0.37) <0.0001
FCSRT, total free and cued delayed recall, mean (SE) 15.8 (0.11) 14.8 (0.14) 13.9 (0.10) 15.8 (0.10) 15.8 (0.11) <0.0001
Digit span, standardised score, mean (SE) 11.2 (0.15) 10.9 (0.20) 9.4 (0.09) 10.4 (0.15) 8.9 (0.16) <0.0001
Rey Complex Figure Test, immediate copy score, mean (SE) 34.0 (0.22) 33.6 (0.29) 32.1 (0.13) 33.8 (0.21) 32.5 (0.22) <0.0001
Rey Complex Figure Test, 3-minute copy score, mean (SE) 19.3 (0.31) 14.4 (0.42) 11.6 (0.19) 18.8 (0.30) 16.4 (0.34) <0.0001
FAB score, mean (SE) 17.5 (0.08) 17.5 (0.11) 15.5 (0.05) 16.5 (0.08) 15.4 (0.09) <0.0001
DO 80 score, mean (SE) 79.5 (0.17) 79.1 (0.22) 77.9 (0.11) 79.2 (0.16) 78.7 (0.17) <0.0001
Hippocampal volume, right, cm3, mean (SE) 2.84 (0.02) 2.77 (0.03) 2.68 (0.01) 2.84 (0.02) 2.78 (0.02) <0.0001
Hippocampal volume, left, cm3, mean (SE) 2.75 (0.02) 2.65 (0.03) 2.60 (0.01) 2.73 (0.02) 2.67 (0.02) <0.0001
Brain parenchymal fraction, %, mean (SE) 81.6 (0.06) 81.5 (0.08) 81.4 (0.04) 81.7 (0.06) 81.4 (0.06) <0.0001
White matter lesion volume, cm3, mean (SE) 7.9 (0.76) 10.5 (1.0) 12.0 (0.46) 9.3 (0.74) 9.3 (0.78) <0.0001
Cortical thickness, right, mm, mean (SE) 2.34 (0.01) 2.33 (0.01) 2.31 (0.003) 2.34 (0.005) 2.32 (0.006) <0.0001
Cortical thickness, left, mm, mean (SE) 2.34 (0.005) 2.33 (0.01) 2.32 (0.003) 2.34 (0.005) 2.32 (0.006) 0.0005
Angular and parietal inferior, right, FDG uptake, mean (SE) 1.79 (0.01) 1.77 (0.02) 1.70 (0.01) 1.79 (0.01) 1.74 (0.01) <0.0001
Parietal inferior, left, FDG uptake, mean (SE) 1.75 (0.01) 1.74 (0.02) 1.67 (0.01) 1.76 (0.01) 1.71 (0.01) <0.0001
Precuneus and cingulum, posterior left, FDG uptake, mean (SE) 2.00 (0.01) 1.97 (0.02) 1.89 (0.01) 1.99 (0.01) 1.94 (0.01) <0.0001
Temporal, inferior left, FDG uptake, mean (SE) 1.65 (0.01) 1.64 (0.01) 1.58 (0.01) 1.65 (0.01) 1.61 (0.01) <0.0001
Temporal, inferior right, FDG uptake, mean (SE) 1.68 (0.01) 1.65 (0.01) 1.60 (0.01) 1.66 (0.01) 1.64 (0.01) <0.0001
  1. Abbreviations: aMCI Amnestic mild cognitive impairment, APOE Apolipoprotein E, CDR Clinical Dementia Rating, DO 80 Dénomination Orale D’images, DMS48 Delayed Matching to Sample 48, FAB Frontal Assessment Battery, FCSRT Free and Cued Selective Reminding Test, FDG 18F-fluorodeoxyglucose, IADL Instrumental Activities of Daily Living, MMSE Mini Mental State Examination, naMCI Non-amnestic mild cognitive impairment, SPPB Short Physical Performance Battery, TMT Trail Making Test
  2. a P value adjusted for centre, age, sex and education level computed from polytomous logistic regression model for categorical variables, generalised linear model for continuous variables