Skip to main content

Table 2 Demographic, clinical and cognitive data of patients with behavioural variant of frontotemporal dementia and patients with Alzheimer’s disease at initial clinical presentation

From: Can cognitive assessment really discriminate early stages of Alzheimer’s and behavioural variant frontotemporal dementia at initial clinical presentation?

  bvFTD (n = 26) AD (n = 43) bvFTD vs. AD Classification as bvFTD vs. AD
Mean (SD) Mean (SD) t(df)
Demographics
 Age, years 65 (8) 72 (9) 3.44 (67)a  
 Education, years 11 (1.7) 11 (1.8) −0.98 (67)
 Sex, M/F 21/5 17/26 N/A
Disease severity scores
 MMSE 26 (3) 24 (3) −2.48 (67)b  
 FBI 28 (10) N/A N/A
 Disease duration, months 29 (19) 23 (14) −1.40 (67)
 Total amyloid-β 850 (424) 397 (108) −4.16 (61)a
 Total tau protein 403 (256) 756 (277) 4.07 (61)a
Neuropsychological assessment
 Memory
  Verbal span −0.77 (0.98) −1.47 (0.99) −2.88 (67)b  
  Verbal learning −1.54 (1.32) −2.36 (1.11) −2.77 (67)b
  Verbal recall −1.74 (1.25) −2.98 (0.77) −5.1 (67)a 0.613
  Verbal recognition −0.77 (1.74) −4.14 (5.25) −3.88 (67)a  
  Visual recall −0.74 (0.95) −1.34 (0.90) −2.62 (67)b
 Language
  Object naming −0.16 (0.94) −1.06 (1.55) −2.99 (67)b  
 Visuospatial skills
  Figure copy 0.16 (1.05) −1.05 (1.85) −3.48 (67)a 0.300
 Executive functions
  Semantic word fluency −1.11 (0.98) −1.21 (1.05) −0.43 (67)  
  Phonematic word fluency −1.13 (0.88) −0.58 (1.14) 2.08 (67)
  Set shifting −1.50 (1.90) −3.18 (2.15) −3.18 (67)a
  Digit span backwards −1.29 (1.39) −1.71 (1.23) −1.26 (67)
 Attention
  Processing speed −0.90 (2.31) −3.48 (3.73) −3.41 (67)a  
 Praxis
  Pantomime of object use −2.51 (2.04) −5.21 (5.90) −2.17 (67)b  
  Imitation of limb postures −2.80 (3.41) −5.39 (4.61) −2.45 (67)b 0.299
  Imitation of face postures −4.88 (4.04) −2.00 (2.50) 3.33 (67)a −0.512
 Social cognition
  Facial emotion recognition −2.35 (2.41) −1.96 (2.10) 0.58 (67)  
  1. Abbreviations: AD Alzheimer’s disease, bvFTD Behavioural variant of frontotemporal dementia, FBI Frontal Behavioral Inventory, MMSE Mini Mental State Examination, N/A Not applicable
  2. Column 1 displays all demographic and clinical categories, cognitive domains and respective standardised subdomains. Columns 2 and 3 display group means and SDs of demographic and clinical categories and of the z-transformed cognitive subdomain scores (refer to Table 1). Column 4 displays the test statistical values resulting from group comparison analysis (Student’s t test). Column 5 displays the standardised canonical discriminant function coefficients resulting from discriminant function analysis. Higher values indicate major importance for successful group classification
  3. aSignificant difference at p < 0.003 (Bonferroni correction for number of cognitive tests)
  4. bSignificant difference at p < 0.05