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Table 2 Antidepressant use and associated risk of head injury among persons with Alzheimer’s disease
| Number of events | Person years | Age-adjusted event rate per 100 person-years (95% CI) | Unadjusted HR (95% CI) | Adjusted HR (95% CI)a | Propensity score adjusted HR (95% CI) | |
|---|---|---|---|---|---|---|
| Users compared with nonusers | ||||||
| Nonusers | 981 | 47,423 | 2.43 (2.06–2.35) | Reference | Reference | Reference |
| Users | 392 | 13,178 | 2.98 (2.49–3.06) | 1.38 (1.23–1.55) | 1.36 (1.21–1.53) | 1.35 (1.20–1.52) |
| Antidepressant use classified according to duration of use | ||||||
| 1–30 days | 37 | 877 | 3.97 (2.70–5.25) | 2.15 (1.35–3.41) | 2.12 (1.33–3.36) | 1.71 (1.10–2.66) |
| 31–180 days | 102 | 3152 | 3.09 (2.49–3.70) | 1.27 (1.00–1.61) | 1.25 (1.00–1.59) | 1.35 (1.06–1.71) |
| 181–365 days | 84 | 2669 | 3.07 (2.41–3.73) | 1.35 (1.05–1.75) | 1.33 (1.03–1.72) | 1.35 (1.05–1.75) |
| 366–731 days | 90 | 3289 | 2.64 (2.10–3.18) | 1.29 (1.01–1.64) | 1.27 (1.00–1.62) | 1.28 (1.01–1.63) |
| > 731 days | 79 | 3213 | 2.29 (1.56–3.01) | 1.50 (1.17–1.93) | 1.48 (1.15–1.91) | 1.35 (1.05–1.74) |
| Drug class specific analyses (n = 38 concomitant users excluded) | ||||||
| Other antidepressant | 110 | 4465 | 2.24 (1.78–2.71) | 1.01 (0.83–1.23) | 0.95 (0.77–1.16) | 0.94 (0.77–1.15) |
| SSRI | 246 | 7664 | 2.74 (2.40–3.99) | 1.32 (1.15–1.52) | 1.28 (1.11–1.48) | 1.26 (1.10–1.45) |
| As-treated analyses restricted to the first 180 days | ||||||
| Nonusers | 248 | 9758 | 2.33 (2.03–2.63) | Reference | Reference | Reference |
| Users | 139 | 4032 | 3.29 (2.74–3.84) | 1.36 (1.11–1.68) | 1.31 (1.06–1.62) | 1.34 (1.08–1.66) |
| Intention-to-treat analyses restricted to the first 180 days | ||||||
| Nonusers | 268 | 10,226 | 2.35 (2.05–2.65) | Reference | Reference | Reference |
| Users | 173 | 5060 | 3.25 (2.76–3.75) | 1.31 (1.08–1.58) | 1.26 (1.03–1.53) | 1.34 (1.10–1.64) |
