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Table 4 Adjusted regression coefficients of MMSE, IADL, and NPI for each anticholinergic score

From: Anticholinergic drugs and functional, cognitive impairment and behavioral disturbances in patients from a memory clinic with subjective cognitive decline or neurocognitive disorders

 

Outcome 1: MMSE

 

Outcome 2: IADL

 

Outcome 3: NPI

 
 

r (95% CI)

Standardized r

p value

R 2

r (95% CI)c

Standardized r

p value

R 2

r (95% CI)d

Standardized r

p value

R 2

ACB

    

–0.23 (–0.40 to –0.07)

–0.12

0.005

28%

0.42 (–0.71 to 1.55)

0.04

0.47

5%

ADS

    

–0.37 (–0.57 to –0.16)

–0.12

0.005

28%

    

ARS

    

–0.39 (–0.68 to –0.10)

–0.11

0.009

27%

    

Chew’s score

    

–0.25 (–0.39 to –0.11)

–0.13

0.003

28%

    

Han’s score

–0.74 (–1.36 to –0.12)a

–0.09

0.02

14%

–0.25 (–0.47 to –0.03)

–0.09

0.03

27%

1.03 (–0.47 to 2.52)

0.07

0.18

5%

Number of drugs with AC properties

–0.67 (–1.03 to –0.32)b

–0.18

<0.001

16%

–0.27 (–0.39 to –0.16)

–0.20

<0.001

30%

0.67 (–0.12 to 1.46)

0.09

0.10

6%

  1. aAdjustment for age, educational level, and hypertension. Gender, current lifestyle, diabetes mellitus, and hypercholesterolemia and total number of drugs were not significant
  2. bAdjustment for age, educational level, total number of drugs, and hypertension. Gender, current lifestyle, diabetes mellitus, and hypercholesterolemia were not significant
  3. cAdjustment for age, gender, educational level, current lifestyle, total number of drugs, and diagnostic stage. Hypertension, diabetes mellitus, and hypercholesterolemia were not significant
  4. dAdjustment for age, diagnostic stage, and total number of drugs. Gender, educational level, current lifestyle, hypertension, diabetes mellitus, and hypercholesterolemia were not significant
  5. AC anticholinergic, ACB Anticholinergic Cognitive Burden, ADS Anticholinergic Drug Scale, ARS Anticholinergic Risk Scale, CI confidence interval, IADL Instrumental Activities of Daily Living, MMSE Mini Mental State Examination, NPI Neuropsychiatric Inventory