Fig. 1From: On the path to 2025: understanding the Alzheimer’s disease continuumChange in biomarkers over time. a Sequential change in measures of AD. Reproduced with permission from [24]. b Modified graph showing that amyloid accumulation (measured as low CSF Aβ or elevated amyloid PET standard uptake value ratio) occurs first and functional decline occurs late in the continuum of AD (as before), but cognitive performance, FDG-PET, tau PET, and MRI atrophy change along a common, gradually steepening curve. Aβ amyloid beta, FDG flurodeoxyglucose, PET positron emission tomography, MCI mild cognitive impairment due to Alzheimer’s diseaseBack to article page