Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

Table 2 Covariates associated with Alzheimer’s disease at end of follow-up with univariate, multivariable and sensitivity analysis of Cox regression analysis

Variable	Univariate analysis			Multivariable analysis
	Crude HR	95% CI	p value	Adjusted HR	95% CI	p value
1-year exclusion in a diagnosis of AD
Chronic periodontitis
Without	Reference			Reference
With	1.301	1.012–1.673	0.0404	1.297	0.995–1.692	0.0547
10-year exclusion in a diagnosis of AD
Chronic periodontitis
Without	Reference			Reference
With	1.364	1.079–1.725	0.0095	1.707	1.152–2.528	0.0077

AD Alzheimer’s disease
The multivariable analyses were adjusted for hypertension, hyperlipidaemia, chronic kidney disease, depression, stroke, traumatic brain injury, diabetes mellitus, Charlson comorbidity index score, urbanisation level