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Table 1 Demographics, Aβ and neuropsychological test scores for each participant group

From: Sensitivity of restriction spectrum imaging to memory and neuropathology in Alzheimer’s disease

 

HC

(n = 31)

MCI

(n = 12)

AD

(n = 13)

Group effect

Age, years

(range)

75.7 ± 5.6

(65–87)

77.4 ± 9.3

(63–93)

78.6 ± 7.8

(64–91)

F(2,53) = 0.85; p = 0.43

Sex (% women)

71%

33%

31%

x2 = 8.47; p = 0.007

Education, years

(range)

15.8 ± 2.4

(8–20)

17.7 ± 2.0

(14–20)

16.0 ± 2.6

(12–20)

F(2,53) = 2.85; p = 0.07

DRS

139.8 ± 1.2

131.7 ± 2.0a

120.7 ± 1.9b,c

F(2,50) = 34.22; p < 0.001

FAQ

0.8 ± 0.8

3.0 ± 1.4

14.6 ± 1.1b,c

F(2,45) = 49.19; p < 0.001

LMI

15.6 ± 1.0

8.7 ± 1.5b

5.4 ± 1.4b

F(2,49) = 18.31; p < 0.001

LMD

14.2 ± 1.1

5.2 ± 1.7b

1.9 ± 1.6b

F(2,49) = 22.20; p < 0.001

CVLT-SFR

10.4 ± 0.5

2.9 ± 0.8b

1.9 ± 0.8b

F(2,45) = 43.36; p < 0.001

CVLT-LFR

11.1 ± 0.4

3.2 ± 0.7b

1.5 ± 0.7b

F(2,45) = 78.42; p < 0.001

CERAD-DR

7.2 ± 0.4

2.8 ± 0.6b

1.0 ± 0.6b

F(2,48) = 38.82; p < 0.001

ANART-VIQ

118.3 ± 1.4

117.4 ± 2.2

115.1 ± 2.0

F(2,46) = 0.85; p = 0.43

 

n = 24

n = 7

n = 7

 

Aβ40, ng/ml

15.8 ± 1.2

11.5 ± 2.5

16.1 ± 2.3

F(2,32) = 1.21; p = 0.31

Aβ42, ng/ml

3.0 ± 0.2

1.5 ± 0.5

2.0 ± 0.4

F(2,32) = 4.58; p = 0.02

  1. Aβ and test scores are corrected for age, sex and education
  2. Values are shown as mean ± standard error unless otherwise noted
  3. a p < 0.01, compared to HC; b p < 0.001, compared to HC; c p < 0.001, compared to MCI, with Bonferroni correction for multiple comparisons
  4. amyloid-β, AD Alzheimer’s disease, ANART-VIQ, American National Reading Test Verbal IQ, CERAD-DR Consortium to Establish a Registry for Alzheimer’s Disease delayed recall, CVLT-LFR California Verbal Learning Test long delay free recall, CVLT-SFR California Verbal Learning Test short delay free recall, DRS Dementia Rating Scale, FAQ Functional Assessment Questionnaire, HC healthy controls, LMI Logical Memory immediate, LMD Logical Memory delayed, MCI mild cognitive impairment