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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: RETRACTED ARTICLE: Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

Fig. 2

ApoE141–148 mediates apoE-induced Aβ42-α7nAChR association enhancement in vitro in a cell-free system. In vitro assessment of the effect of 0.01–100 μM apoE fragments on the Aβ42-α7nAChR interaction in biotin-tagged α7nAChRs trapped on a streptavidin-coated 96-well plate. The apoE fragments were added simultaneously with a or 10 min prior to b 20 nM FITC-conjugated Aβ42. The level of Aβ42-α7nAChR association was measured by the residual FITC signals. The data are mean ± SEM of the percentage change from vehicle-treated wells (n = 6). *p < 0.01, **p < 0.05, compared to vehicle control by Newman-Keuls multiple comparisons. ApoE apolipoprotein E

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Alzheimer's Research & Therapy

ISSN: 1758-9193