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Table 2 Structural neuroanatomical associations of speech signal analysis in the patient cohort

From: Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias

Contrast

Region

Side

Cluster (voxels)

Peak (mm)

t value

p value

x

y

z

Temporal regularity

Supplementary motora

Left

427

–2

–9

63

7.93

0.016

 

Caudate

Right

216

16

–2

20

7.02

0.042

Phonemic structure

Supramarginal gyrusa

Left

12

–58

–28

14

5.53

0.026

Prosodic predictability

Putamen

Right

289

28

0

6

7.01

0.035

  1. Summary of statistically significant positive associations between grey matter volume and performance on psychoacoustic tasks to assess the temporal regularity, phonemic structure and prosodic predictability of experimental speech stimuli (see text for details), based on a voxel-based morphometric analysis of brain magnetic resonance images for the combined patient cohort. All values were significant at p < 0.05FWE within a pre-specified neuroanatomical region of interest (see Additional file 9); coordinates of local maxima are in MNI standard space
  2. FWE family-wise error
  3. aLocal maximum coincident with regional disease-related grey matter atrophy in the non-fluent variant primary progressive aphasia group (see Additional file 11)