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Table 1 Half-maximal effective concentrations of J147 and CAD-31 in six assays

From: A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism

Assay Cell type J147 (nM) CAD-31 (nM)
Trophic factor withdrawal Cortical neuron 35 18
BDNF-like activity HT22 74 95
Oxytosis Cortical neuron 6 20
In vitro ischemia HT22 14 47
Aβ toxicity (extracellular) Hippocampal neuron 15 27
Aβ toxicity (intracellular) MC65 10 12
  1. β-Amyloid, BDNF Brain-derived neurotrophic factor