Fig. 7From: A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolismMetabolic analysis of plasma shows effects on lipid metabolism. Heat map of average levels of lipids from the plasma grouped by class. a General trends showed that CAD-31 had its largest effect on ketone bodies, acyl carnitine, long-chain fatty acids, and sphingolipids. b Metabolite enrichment scores were generated, and metabolite groups significantly changed were determined. Individual significantly changed metabolites from the enriched pathways were plotted. c The control (C), CAD-31-treated control (C + 31), Alzheimer’s mice (AD), and AD mice treated with CAD-31 (AD + 31) metabolite levels are color-coordinated to the enrichment graph. The control compared with the CAD-31-treated control and the AD vs CAD-31-treated AD group demonstrated general trends in lipid metabolism. One-way analysis of variance and Tukey’s post hoc test were used to determine statistical significance. * p < 0.05Back to article page