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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism

Fig. 7

Metabolic analysis of plasma shows effects on lipid metabolism. Heat map of average levels of lipids from the plasma grouped by class. a General trends showed that CAD-31 had its largest effect on ketone bodies, acyl carnitine, long-chain fatty acids, and sphingolipids. b Metabolite enrichment scores were generated, and metabolite groups significantly changed were determined. Individual significantly changed metabolites from the enriched pathways were plotted. c The control (C), CAD-31-treated control (C + 31), Alzheimer’s mice (AD), and AD mice treated with CAD-31 (AD + 31) metabolite levels are color-coordinated to the enrichment graph. The control compared with the CAD-31-treated control and the AD vs CAD-31-treated AD group demonstrated general trends in lipid metabolism. One-way analysis of variance and Tukey’s post hoc test were used to determine statistical significance. * p < 0.05

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