| |
AD panel
| |
p-taurel
|
Aβ1–42/p-taurel
|
p-tau181/p-taurel
|
|---|
|
AD vs. non-AD
|
p-tau181
|
0.883
|
0.619$
| | |
|
Aβ1–42/p-tau181
|
0.860
| |
0.657$
| |
|
AD vs. FTLD
|
p-tau181
|
0.933
|
0.799$
| | |
|
Aβ1–42/p-tau181
|
0.920
| |
0.846$
| |
|
AD vs. DLB
|
t-tau
|
0.863
|
0.706$
| | |
|
Aβ1–42/t-tau
|
0.855
| |
0.747$
| |
|
AD vs. CJD
|
t-tau
|
0.896
|
0.978*
| | |
|
p-tau181/t-tau
|
1.000
| | |
1.000
|
|
AD vs. controls
|
t-tau
|
0.926
|
0.865
| | |
|
Aβ1–42/t-tau
|
0.976
| |
0.949
| |
|
FTLD vs. controls
|
Aβ1–42
|
0.679
|
0.588
| | |
|
p-tau181/t-tau
|
0.827
| | |
0.695
|
|
DLB vs. controls
|
Aβ1–42
|
0.747
|
0.717
| | |
|
Aβ1–42/p-tau181
|
0.739
| |
0.815
| |
|
CJD vs. controls
|
t-tau
|
0.978
|
1.000
| | |
|
Aβ1–42/t-tau
|
1.000
| |
1.000
| |
- The third column contains AUC values for the established single markers and biomarker ratios with the highest diagnostic value
- Adjacent columns show AUC values of p-taurel and the equivalent ratio using p-taurel
- Significant differences between AUC values (DeLong tests, p < 0.05) are marked by an asterisk (*) when diagnostic power is significantly higher with addition of p-taurel, and by a dollar sign ($) when diagnostic power is significantly lower with addition of p-taurel
-
Aβ
1–42
amyloid-beta of 42 amino acids, AD Alzheimer’s disease, CJD Creutzfeldt-Jakob disease, CSF cerebrospinal fluid, DLB dementia with Lewy bodies, FTLD frontotemporal lobar degeneration, p-tau
181
tau protein phosphorylated at threonine 181, p-tau
rel
non-phosphorylated tau fraction, t-tau total tau protein
