Fig. 4

Tg4510 mice presented spatial memory deficits in the RAWM and reversal trial that were not rescued by TOMA treatment. Number of errors during 2-day RAWM (a) and reversal (b) in nontransgenic mice (nTg, white bars), Tet-only mice (Tet, grey bars), and Tg4510 mice treated with IgG1 (Tg4510 IgG1, black bars) or TOMA (Tg4510 TOMA, striped bars) for 5 months. Tg4510 mice made significantly more errors attempting to locate a hidden platform in the 2-day RAWM test, compared to nTg mice and Tet mice, regardless of the treatment. Tg4510 mice were not able to learn a new platform location on the reversal trial. Data presented as mean ± SEM, n = 10/group. *p = 0.05. RAWM radial arm water maze, TOMA tau oligomer monoclonal antibody, nb Number