Fig. 2

TOMA recognizes high molecular weight tau in material from Tg4510 mice. Western blot image from Tg4510 mouse cortex a. Some mice were treated with doxycycline to suppress transgene expression for 6 or 16 weeks (row labeled “Dox”). 0, no doxycycline treatment. Ages of the mice are also indicated in months in the row labeled “Age”. Molecular weight marker locations are indicted by arrows along the Y axis. b Merged immunofluorescence micrograph staining for the total tau antibody, Tau-5 (green), TOMA (red), and DAPI to stain nuclei (blue). Yellow areas indicate overlap of the Tau-5 and TOMA staining (Color figure online). TOMA tau oligomer monoclonal antibody