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Table 4 Characteristics of the patients with dual disease (Alzheimer’s disease and dementia with Lewy bodies) from the Memory Resource and Research Centre of Strasbourg

From: Long-term cognitive outcome of Alzheimer’s disease and dementia with Lewy bodies: dual disease is worse

Patients

Initial MMSE score

Memory storage deficit

Language deficit

Executive deficit

Visuospatial and/or visuoperceptive and/or visuoconstructive deficit

Visual hallucinations

Fluctuations

Parkinsonism

RBD

Hippocampal atrophy on brain MRI

CSF

FDG-PET or perfusion SPECT

AD or DLB diagnosed first

Years between diagnoses

DAT, flutemetamol, EEG

1

18

Yes

Yes

Yes

Yesa

Yesa

Yesa

Yesa

No

Yes (left)

3

Hypometabolism frontal, parietal, insular

AD

4

 

2

22

Yes

Yes

Yes

Yes

Yesa

Yesa

No

Yes

Yes

ND

Hypometabolism temporal, occipital

AD

3

 

3

24

No

No

Yes

Yes

Yes

Yes

Yes

No

Yes

3

hypometabolism frontal, temporal, parietal

DLB

1

Slow wave EEG

4

26

Yes

No

Yes

Yes

Yes

No

Yes

No

Yes

1 (P-Tau)

Hypometabolism frontal, temporal, parietal

AD

6

 

5

25

Yes

Yes

Yes

ND

Yes

Yes

Yes

No

Yes

1 (Aβ)

hypometabolism frontal, parietal, occipital

AD

5

 

6

24

Yes

No

Yes

Yes

Yesa

Yesa

No

No

Yes (left)

2 (tau, p-tau)

hypometabolism temporal, parietal, occipital

AD

5

 

7

16

Yes

Yes

Yes

Yes

Yesa

Yes

No

No

Yes (right)

3

Hypometabolism temporal, parietal

AD

2

 

8

24

Yes

No

Yes

No

Yesa

Yesa

Yesa

Yesa

No

2 (tau, p-tau)

ND

AD

4

 

9

21

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

2 (p-tau, Aβ)

Hypoperfusion frontal, temporal, occipital

DLB

3

Pathological DAT slow wave EEG

10

25

Yes

Yes

Yes

Yes

Yes

Yes

Yes

No

No

ND

ND

AD

1

Pathological DAT slow wave EEG

11

25

Yes

No

Yes

No

Yesa

Yesa

Yesa

No

Yes

ND

ND

AD

6

 

12

26

Yes

Yes

Yes

Yesa

Yesa

Yesa

Yesa

No

No

3

ND

AD

4

Pathological PET with flutemetamol

13

28

Yes

No

Yes

Yes

Yesa

Yesa

Yesa

No

Yes

ND

ND

AD

3

Pathological DAT scan

14

24

Yes

No

No

No

Yesa

Yesa

No

No

Yes

ND

Hypoperfusion temporal, occipital

AD

5

 

15

20

Yes

No

Yes

Yes

Yesa

Yes

Yes

No

Yes

ND

Hypoperfusion temporal, parietal, insular

DLB

2

Pathological DAT scan

16

22

Yes

No

No

No

Yesa

Yesa

Yesa

No

Yes

3

Hypoperfusion temporal

AD

7

 

17

26

Yes

No

Yes

No

No

Yesa

Yesa

Yes

No

ND

ND

AD

1

Pathological PET with flutemetamol

18

24

Yes

No

Yes

No

Yesa

Yesa

No

Yesa

Yes (right)

0

ND

AD

3

 

19

24

No

No

Yes

No

Yesa

Yes

Yesa

No

Yes

0

Hypoperfusion temporal, parietal, insular

DLB

4

Pathological PET with flutemetamol

  1. Abbreviations: Aβ Amyloid-β, AD Alzheimer’s disease, CSF Cerebrospinal fluid, DAT Dopamine transporter scan, DLB Dementia with Lewy bodies, EEG Electroencephalogram, FDG-PET Fluorodeoxyglucose positron emission tomography, MMSE Mini Mental State Examination, MRI Magnetic resonance imaging, ND Not done p-tau Phosphorylated tau, RBD Rapid eye movement sleep behaviour disorder SPECT Single-photon emission computed tomography
  2. a Symptoms arising during follow-up and not at the beginning