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Table 4 Characteristics of the patients with dual disease (Alzheimer’s disease and dementia with Lewy bodies) from the Memory Resource and Research Centre of Strasbourg

From: Long-term cognitive outcome of Alzheimer’s disease and dementia with Lewy bodies: dual disease is worse

Patients Initial MMSE score Memory storage deficit Language deficit Executive deficit Visuospatial and/or visuoperceptive and/or visuoconstructive deficit Visual hallucinations Fluctuations Parkinsonism RBD Hippocampal atrophy on brain MRI CSF FDG-PET or perfusion SPECT AD or DLB diagnosed first Years between diagnoses DAT, flutemetamol, EEG
1 18 Yes Yes Yes Yesa Yesa Yesa Yesa No Yes (left) 3 Hypometabolism frontal, parietal, insular AD 4  
2 22 Yes Yes Yes Yes Yesa Yesa No Yes Yes ND Hypometabolism temporal, occipital AD 3  
3 24 No No Yes Yes Yes Yes Yes No Yes 3 hypometabolism frontal, temporal, parietal DLB 1 Slow wave EEG
4 26 Yes No Yes Yes Yes No Yes No Yes 1 (P-Tau) Hypometabolism frontal, temporal, parietal AD 6  
5 25 Yes Yes Yes ND Yes Yes Yes No Yes 1 (Aβ) hypometabolism frontal, parietal, occipital AD 5  
6 24 Yes No Yes Yes Yesa Yesa No No Yes (left) 2 (tau, p-tau) hypometabolism temporal, parietal, occipital AD 5  
7 16 Yes Yes Yes Yes Yesa Yes No No Yes (right) 3 Hypometabolism temporal, parietal AD 2  
8 24 Yes No Yes No Yesa Yesa Yesa Yesa No 2 (tau, p-tau) ND AD 4  
9 21 Yes Yes Yes Yes Yes Yes Yes Yes Yes 2 (p-tau, Aβ) Hypoperfusion frontal, temporal, occipital DLB 3 Pathological DAT slow wave EEG
10 25 Yes Yes Yes Yes Yes Yes Yes No No ND ND AD 1 Pathological DAT slow wave EEG
11 25 Yes No Yes No Yesa Yesa Yesa No Yes ND ND AD 6  
12 26 Yes Yes Yes Yesa Yesa Yesa Yesa No No 3 ND AD 4 Pathological PET with flutemetamol
13 28 Yes No Yes Yes Yesa Yesa Yesa No Yes ND ND AD 3 Pathological DAT scan
14 24 Yes No No No Yesa Yesa No No Yes ND Hypoperfusion temporal, occipital AD 5  
15 20 Yes No Yes Yes Yesa Yes Yes No Yes ND Hypoperfusion temporal, parietal, insular DLB 2 Pathological DAT scan
16 22 Yes No No No Yesa Yesa Yesa No Yes 3 Hypoperfusion temporal AD 7  
17 26 Yes No Yes No No Yesa Yesa Yes No ND ND AD 1 Pathological PET with flutemetamol
18 24 Yes No Yes No Yesa Yesa No Yesa Yes (right) 0 ND AD 3  
19 24 No No Yes No Yesa Yes Yesa No Yes 0 Hypoperfusion temporal, parietal, insular DLB 4 Pathological PET with flutemetamol
  1. Abbreviations: Aβ Amyloid-β, AD Alzheimer’s disease, CSF Cerebrospinal fluid, DAT Dopamine transporter scan, DLB Dementia with Lewy bodies, EEG Electroencephalogram, FDG-PET Fluorodeoxyglucose positron emission tomography, MMSE Mini Mental State Examination, MRI Magnetic resonance imaging, ND Not done p-tau Phosphorylated tau, RBD Rapid eye movement sleep behaviour disorder SPECT Single-photon emission computed tomography
  2. a Symptoms arising during follow-up and not at the beginning
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Alzheimer's Research & Therapy

ISSN: 1758-9193