Skip to main content

Table 1 Characteristics of participants by gender

From: Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults

 

CSF AD biomarker sample

CSF vascular biomarker sample

Female

(n = 178)

Male

(n = 153)

Female

(n = 141)

Male

(n = 108)

Age (years)

57.5 (16.8)

(21–100)

56.0 (19.6)

(22–88)

70.0 (8.5)

(50–100)

72.1 (9.1)

(50–90)

BMI (kg/m2)

25.8 (4.3)

(18–41)

26.4 (3.4)

(20–37)

25.7 (4.3)

(18–39)

26.3 (3.0)

(20–36)

Education (years)

15.8 (2.5)

(10–22)

16.5 (2.8)*

(10–27)

15.8 (2.5)

(9–23)

16.2 (2.6)

(10–25)

MMSE score

29.3 (0.9)

(26–30)

29.2 (1.2)

(25–30)

29.5 (0.9)

(25–30)

28.8 (1.4)*

(24–30)

APOE-ε4 positive, n (%)

67 (38)

48 (31)

49/136 (36)

33/100 (33)

Aβ42 (pg/ml)

331 (135)

(63–821)

323 (116)

(98–801)

  

Total tau (pg/ml)

47.9 (13.4)

(7–91)

50.5 (15.0)

(18–130)

  

p-tau181 (pg/ml)

31.3 (8.4)

(<7–67)

32.6 (12.7)

(9–107)

  

E-selectin (pg/ml)

  

42.1 (33.2)

(1.5–188)

60.3 (42.1)

(1.5–226)

VCAM1 (ng/ml)

  

115 (59)

(34–343)

147 (70)

(42–429)

  1. Data presented as mean (standard deviation) (range), unless stated otherwise
  2. Aβ 42 amyloid beta1–42, AD Alzheimer’s disease, APOE apolipoprotein E, BMI body mass index, CSF cerebrospinal fluid, MMSE Mini-Mental State Examination, p-tau 181 phospho-tau-181, VCAM1 vascular cell adhesion protein 1
  3. *p < 0.05 for gender difference within each cohort by t test or χ2 test