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Table 3 Regression coefficients in linear model with cerebrospinal fluid tau phosphorylated at threonine 181 and tau as dependent variables of interaction terms between biomarkers and different variables

From: One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Interaction term CSF cystathionine CSF SAH CSF 5-MTHF Plasma Hcy
CSF p-tau181
 Age −0.0011 −0.0098 0.0036 0.0113
 Sexa −0.0652 −0.4815b 0.3443 −0.6850b
APOE ε4 genotypec 0.2169 0.5126b −0.5687b 1.1427d
 CDR categorye 0.1877 0.2122 −0.2434 0.2833
CSF tau
 Age   −0.0076 0.0099  
 Sexa   −0.7407f 0.4541  
APOE ε4 genotypec   0.4953 −0.6965  
 CDR categorye   0.1352 −0.2681  
  1. Abbreviations: APOE Apolipoprotein E, CDR Clinical Dementia Rating, CSF Cerebrospinal fluid, Hcy Homocysteine, 5-MTHF 5-Methyltetrahydrofolate, p-tau181 Tau phosphorylated at threonine 181, SAH S-adenosyl-L-homocysteine
  2. Every interaction was tested in separate models, with only one interaction per model. Values of the regression interaction terms are reported, and their difference from 0 was assessed with an F test in analysis of variance
  3. aFemales (versus reference males)
  4. b p ≤ 0.05
  5. c APOE ε4 carriers (versus reference noncarriers)
  6. d p ≤ 0.001
  7. eCDR >0 (versus reference CDR 0)
  8. f p ≤ 0.01