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Table 2 Regression coefficients in linear model with cerebrospinal fluid tau phosphorylated at threonine 181 and tau as dependent variables

From: One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Regression term CSF cystathionine CSF SAH CSF 5-MTHF Plasma Hcy
CSF p-tau181
 Intercept 1.0719a 1.0503a 2.1744a 1.1802a
 Age 0.0063b 0.0038 0.0045c 0.0054c
 Sexd −0.0279 −0.0223 −0.0140 −0.0236
APOE ε4 genotypee 0.0328 0.0195 0.0362 0.0314
 CDR categoryf 0.1173b 0.1182b 0.1110b 0.1186b
 Biomarker 0.1120 0.3195b −0.4965a 0.1670
CSF tau
 Intercept   1.4134a 2.8174a  
 Age   0.0073c 0.0080c  
 Sexd   −0.0215 −0.0108  
APOE ε4 genotypee   0.0692 0.0894  
 CDR categoryf   0.1758a 0.1665b  
 Biomarker   0.3803b −0.6269a  
  1. Abbreviations: Aβ β-Amyloid, APOE Apolipoprotein E, CDR Clinical Dementia Rating, CSF Cerebrospinal fluid, Hcy Homocysteine, 5-MTHF 5-Methyltetrahydrofolate, p-tau181 Tau phosphorylated at threonine 181, SAH S-adenosyl-L-homocysteine
  2. Values of the regression terms are reported, and their differences from 0 were assessed with a t test
  3. a p ≤ 0.001
  4. b p ≤ 0.01
  5. c p ≤ 0.05
  6. dFemales (versus reference males)
  7. e APOE ε4 carriers (versus reference noncarriers)
  8. f CDR >0 (versus reference CDR 0)