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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Fig. 3

Association of homocysteine (Hcy) levels measured in plasma with cerebrospinal fluid (CSF) tau phosphorylated at threonine 181 (p-tau181), stratified by the presence of the apolipoprotein E (APOE) ε4 allele (a). The correlation between expression levels of plasma Hcy and CSF p-tau181 differs according to APOE genotype. ROC curves of the models predictive of non-Alzheimer disease (non-AD) versus AD CSF profiles (i.e., p-tau181/Aβ1–42 ≤ 0.0779 and p-tau181/Aβ1–42 > 0.0779, respectively) (b). The ROC curves of the least absolute shrinkage and selection operator (LASSO) models including metabolites in plasma (in red) are compared with the ROC curves of the reference LASSO models (in blue). The plasma model (in red) includes glycine, methionine, S-adenosyl-L-homocysteine (SAH), S-adenosylmethionine (SAM), serine, cysteine, and Hcy in addition to age, sex, years of education, and CSF albumin index. The reference model (in blue) includes age and years of education. The opacity of the curves is proportional to the accuracy of the models. The diamonds indicate the selected most accurate models. The p value on the graph indicates the significance of the differences of AUC. APOE Apolipoprotein E, HCY Homocysteine, SAH S-adenosyl-L-homocysteine, SAM S-adenosylmethionine

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