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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Fig. 1

ROC curves of the (a) cerebrospinal fluid (CSF) and (b) plasma models predictive of cognitive impairment (Clinical Dementia Rating [CDR] 0 or >0). The CSF model includes cystathionine, methionine, S-adenosyl-L-homocysteine (SAH), S-adenosylmethionine (SAM), serine, cysteine, and 5-methyltetrahydrofolate (5-MTHF) in addition to age, years of education, CSF β-amyloid 1–42 peptide chain (Aβ1–42), CSF tau, CSF tau phosphorylated at threonine 181 (p-tau181), and CSF albumin index. The plasma model includes cystathionine, glycine, methionine, SAH, SAM, serine, cysteine, and homocysteine (Hcy) in addition to age, sex, years of education, presence of apolipoprotein E (APOE) ε4 allele, CSF Aβ1–42, CSF tau, CSF p-tau181, and CSF albumin index. The ROC curves of the least absolute shrinkage and selection operator (LASSO) models including metabolites (in red) are compared with the ROC curves of the reference LASSO models (in blue). The reference model is composed of age, years of education, CSF Aβ1–42, CSF tau, and CSF p-tau181. The opacity of the curves is proportional to the accuracy of the models. The diamonds indicate the selected most accurate models. The p values on the graphs indicate the significance of the differences of AUC. APOE Apolipoprotein E, HCY Homocysteine, 5-MTHF 5-Methyltetrahydrofolate, SAH S-adenosyl-L-homocysteine, SAM S-adenosylmethionine

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