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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

Fig. 7

EBY100-L2 (AOE1) vaccination decreased activated astrocytes and microglia in the hippocampus and cortex of Alzheimer’s disease (AD) mice. a Astrocytes in the cortex and hippocampus of brain slices were determined by immunohistochemistry (IHC) using glial fibrillary acidic protein (GFAP) monoclonal antibody, and then the stained astrocytes were quantified using IpWin5 software (c) (compared with AD control, *p < 0.05, **p < 0.01). b Microglia in the cortex and hippocampus of brain slices were detected by IHC using ionized calcium-binding adaptor molecule-1 (Iba-1) polyclonal antibody, and then the stained microglia were quantified using IpWin5 software (d) (compared with AD control, *p < 0.05, **p < 0.01). β-Amyloid peptide, WT Wild type

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