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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

Fig. 2

The titer and subtype of antibody in Alzheimer’s disease (AD) transgenic mice immunized with EBY100-L2 vaccine (AOE1). APP/PS1 mice (male, 6 months of age) were subcutaneously injected eight times at 2-week intervals with AOE1, Aβ15, and EBY100 control cells in the absence of adjuvant. The titers and subtypes of antibody in the mouse sera were detected by enzyme-linked immunosorbent assay. a The titers of antibody against mimotope peptide L2 in the mice immunized with AOE1 vaccine. b The titers of antibody against Aβ42 oligomers in the mice immunized with AOE1 vaccine. c Subtype of immunoglobulin G against Aβ42 oligomers. OD450 Optical density at 450 nm

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Alzheimer's Research & Therapy

ISSN: 1758-9193