All-cause dementia | Alzheimer disease (AD) | Vascular dementia (VaD) | Mixed AD/VaD | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | NCa | OR (95% CI) | NCa | OR (95% CI) | NCa | OR (95% CI) | NCa | |||||
(1) Study sample (n = 24,638) | HUNT 1 | HUNT 2 | 579 | HUNT 1 | HUNT 2 | 383 | HUNT 1 | HUNT 2 | 118 | HUNT 1 | HUNT 2 | 78 |
Model 1b | 1.16 (1.12–1.20) g | 1.16 (1.12–1.19) | 1.15 (1.10–1.20) | 1.14 (1.10–1.19) | 1.18 (1.10–1.28) | 1.19 (1.10–1.27) | 1.15 (1.04–1.26) | 1.18 (1.08–1.29) | ||||
Model 2c | 0.94 (0.89–0.99) | 1.03 (0.98–1.09) | 0.95 (0.91–1.02) | 1.04 (0.98–1.10) | 0.96 (0.86–1.07) | 1.02 (.92–1.14) | 0.83 (0.72–0.96) | 1.04 (0.92–1.18) | ||||
Model 3d | 0.93 (0.88–0.98) | 1.01 (0.96–1.06) | 0.94 (0.88–1.01) | 1.01 (0.95–1.07) | 0.96 (0.85–1.07) | 1.01 (.90–1.12) | 0.82 (0.71–0.95) | 1.03 (0.90–1.18) | ||||
Model 4e | 0.92 (0.87–0.97) | 1.01 (0.96–1.07) | 0.94 (0.88–1.00) | 1.01 (0.95–1.07) | 0.95 (0.84–1.06) | 1.01 (.90–1.13) | 0.82 (0.71–0.95) | 1.04 (0.91–1.18) | ||||
(2) Aged <60 yearsf (n = 18,693) | 251 | 159 | 60 | 32 | ||||||||
Model 1 | 1.21 (1.15–1.28) | 1.19 (1.13–1.25) | 1.21 (1.13–1.30) | 1.19 (1.12–1.27) | 1.19 (1.01–1.40) | 1.26 (1.08–1.47) | 0.82 (0.63–1.08) | 1.39 (1.14–1.69) | ||||
Model 2 | 1.02 (0.93–1.11) | 1.09 (1.01–1.18) | 1.08 (0.97–1.20) | 1.11 (1.01–1.23) | 1.04 (0.87–1.23) | 1.03 (.88–1.22) | 0.68 (0.52–0.90) | 1.07 (0.87–1.33) | ||||
Model 3 | 1.01 (0.93–1.10) | 1.08 (0.99–1.17) | 1.08 (0.97–1.20) | 1.11 (1.00–1.22) | 1.03 (0.87–1.23) | 1.02 (.86–1.20) | 0.68 (0.52–0.89) | 1.05 (0.85–1.31) | ||||
Model 4 | 1.01 (0.92–1.10) | 1.08 (0.99–1.17) | 1.09 (0.97–1.21) | 1.11 (1.00–1.22) | 1.01 (0.85–1.21) | 1.01 (.86–1.20) | 0.67 (0.50–0.89) | 1.08 (0.86–1.34) | ||||
(3) Aged >60 yearsf (n = 5945) | 328 | 224 | 58 | 46 | ||||||||
Model 1 | 0.90 (0.84–0.96) | 0.96 (0.90–1.02) | 0.90 (0.83–0.97) | 0.95 (0.88–1.02) | 0.92 (0.79–1.06) | 0.98 (.85–1.12) | 0.91 (0.77–1.07) | 0.98 (0.84–1.15) | ||||
Model 2 | 0.94 (0.88–0.99) | 0.98 (0.92–1.04) | 0.93 (0.86–1.01) | 0.97 (0.90–1.05) | 0.94 (0.81–1.10) | 0.99 (.86–1.14) | 0.94 (0.79–1.11) | 1.00 (0.85–1.18) | ||||
Model 3 | 0.92 (0.86–0.99) | 0.96 (0.90–1.03) | 0.92 (0.84–0.99) | 0.95 (0.88–1.02) | 0.94 (0.81–1.09) | 0.98 (.85–1.14) | 0.94 (0.79–1.11) | 1.00 (0.85–1.19) | ||||
Model 4 | 0.92 (0.85–0.98) | 0.96 (0.90–1.02) | 0.91 (0.83–0.98) | 0.94 (0.87–1.02) | 0.94 (0.81–1.10) | 0.99 (.86–1.16) | 0.92 (0.77–1.10) | 0.99 (0.83–1.17) |