|
All-cause dementia
|
Alzheimer disease (AD)
|
Vascular dementia (VaD)
|
Mixed AD/VaD
|
---|
OR (95% CI)
|
NCa
|
OR (95% CI)
|
NCa
|
OR (95% CI)
|
NCa
|
OR (95% CI)
|
NCa
|
---|
(1) Study sample (n = 24,638)
|
HUNT 1
|
HUNT 2
|
579
|
HUNT 1
|
HUNT 2
|
383
|
HUNT 1
|
HUNT 2
|
118
|
HUNT 1
|
HUNT 2
|
78
|
Model 1b
|
1.16 (1.12–1.20)
g
|
1.16 (1.12–1.19)
| |
1.15 (1.10–1.20)
|
1.14 (1.10–1.19)
| |
1.18 (1.10–1.28)
|
1.19 (1.10–1.27)
| |
1.15 (1.04–1.26)
|
1.18 (1.08–1.29)
| |
Model 2c
|
0.94 (0.89–0.99)
|
1.03 (0.98–1.09)
| |
0.95 (0.91–1.02)
|
1.04 (0.98–1.10)
| |
0.96 (0.86–1.07)
|
1.02 (.92–1.14)
| |
0.83 (0.72–0.96)
|
1.04 (0.92–1.18)
| |
Model 3d
|
0.93 (0.88–0.98)
|
1.01 (0.96–1.06)
| |
0.94 (0.88–1.01)
|
1.01 (0.95–1.07)
| |
0.96 (0.85–1.07)
|
1.01 (.90–1.12)
| |
0.82 (0.71–0.95)
|
1.03 (0.90–1.18)
| |
Model 4e
|
0.92 (0.87–0.97)
|
1.01 (0.96–1.07)
| |
0.94 (0.88–1.00)
|
1.01 (0.95–1.07)
| |
0.95 (0.84–1.06)
|
1.01 (.90–1.13)
| |
0.82 (0.71–0.95)
|
1.04 (0.91–1.18)
| |
(2) Aged <60 yearsf (n = 18,693)
| | |
251
| | |
159
| | |
60
| | |
32
|
Model 1
|
1.21 (1.15–1.28)
|
1.19 (1.13–1.25)
| |
1.21 (1.13–1.30)
|
1.19 (1.12–1.27)
| |
1.19 (1.01–1.40)
|
1.26 (1.08–1.47)
| |
0.82 (0.63–1.08)
|
1.39 (1.14–1.69)
| |
Model 2
|
1.02 (0.93–1.11)
|
1.09 (1.01–1.18)
| |
1.08 (0.97–1.20)
|
1.11 (1.01–1.23)
| |
1.04 (0.87–1.23)
|
1.03 (.88–1.22)
| |
0.68 (0.52–0.90)
|
1.07 (0.87–1.33)
| |
Model 3
|
1.01 (0.93–1.10)
|
1.08 (0.99–1.17)
| |
1.08 (0.97–1.20)
|
1.11 (1.00–1.22)
| |
1.03 (0.87–1.23)
|
1.02 (.86–1.20)
| |
0.68 (0.52–0.89)
|
1.05 (0.85–1.31)
| |
Model 4
|
1.01 (0.92–1.10)
|
1.08 (0.99–1.17)
| |
1.09 (0.97–1.21)
|
1.11 (1.00–1.22)
| |
1.01 (0.85–1.21)
|
1.01 (.86–1.20)
| |
0.67 (0.50–0.89)
|
1.08 (0.86–1.34)
| |
(3) Aged >60 yearsf (n = 5945)
| | |
328
| | |
224
| | |
58
| | |
46
|
Model 1
|
0.90 (0.84–0.96)
|
0.96 (0.90–1.02)
| |
0.90 (0.83–0.97)
|
0.95 (0.88–1.02)
| |
0.92 (0.79–1.06)
|
0.98 (.85–1.12)
| |
0.91 (0.77–1.07)
|
0.98 (0.84–1.15)
| |
Model 2
|
0.94 (0.88–0.99)
|
0.98 (0.92–1.04)
| |
0.93 (0.86–1.01)
|
0.97 (0.90–1.05)
| |
0.94 (0.81–1.10)
|
0.99 (.86–1.14)
| |
0.94 (0.79–1.11)
|
1.00 (0.85–1.18)
| |
Model 3
|
0.92 (0.86–0.99)
|
0.96 (0.90–1.03)
| |
0.92 (0.84–0.99)
|
0.95 (0.88–1.02)
| |
0.94 (0.81–1.09)
|
0.98 (.85–1.14)
| |
0.94 (0.79–1.11)
|
1.00 (0.85–1.19)
| |
Model 4
|
0.92 (0.85–0.98)
|
0.96 (0.90–1.02)
| |
0.91 (0.83–0.98)
|
0.94 (0.87–1.02)
| |
0.94 (0.81–1.10)
|
0.99 (.86–1.16)
| |
0.92 (0.77–1.10)
|
0.99 (0.83–1.17)
| |
-
HUNT 1 Helse Undersøkelse Nord-Trøndelag (1984–1986), HUNT 2 Helse Undersøkelse Nord-Trøndelag (1995–1997)
-
aNumber of dementia cases
-
bModel 1: systolic blood pressure
-
cModel 2: systolic blood pressure, age, sex, education
-
dModel 3: systolic blood pressure, age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, pulse
-
eModel 4: systolic blood pressure, age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status, physical activity, blood pressure medication, alcohol use
-
fAge when examined in HUNT 1
-
gp-value <0.05
- The bold text represents p-value <=.05