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Table 2 Multiple logistic regression analyses on the association of systolic blood pressure and dementia

From: Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study

 

All-cause dementia

Alzheimer disease (AD)

Vascular dementia (VaD)

Mixed AD/VaD

OR (95% CI)

NCa

OR (95% CI)

NCa

OR (95% CI)

NCa

OR (95% CI)

NCa

(1) Study sample (n = 24,638)

HUNT 1

HUNT 2

579

HUNT 1

HUNT 2

383

HUNT 1

HUNT 2

118

HUNT 1

HUNT 2

78

 Model 1b

1.16 (1.12–1.20) g

1.16 (1.12–1.19)

 

1.15 (1.10–1.20)

1.14 (1.10–1.19)

 

1.18 (1.10–1.28)

1.19 (1.10–1.27)

 

1.15 (1.04–1.26)

1.18 (1.08–1.29)

 

 Model 2c

0.94 (0.89–0.99)

1.03 (0.98–1.09)

 

0.95 (0.91–1.02)

1.04 (0.98–1.10)

 

0.96 (0.86–1.07)

1.02 (.92–1.14)

 

0.83 (0.72–0.96)

1.04 (0.92–1.18)

 

 Model 3d

0.93 (0.88–0.98)

1.01 (0.96–1.06)

 

0.94 (0.88–1.01)

1.01 (0.95–1.07)

 

0.96 (0.85–1.07)

1.01 (.90–1.12)

 

0.82 (0.71–0.95)

1.03 (0.90–1.18)

 

 Model 4e

0.92 (0.87–0.97)

1.01 (0.96–1.07)

 

0.94 (0.88–1.00)

1.01 (0.95–1.07)

 

0.95 (0.84–1.06)

1.01 (.90–1.13)

 

0.82 (0.71–0.95)

1.04 (0.91–1.18)

 

(2) Aged <60 yearsf (n = 18,693)

  

251

  

159

  

60

  

32

 Model 1

1.21 (1.15–1.28)

1.19 (1.13–1.25)

 

1.21 (1.13–1.30)

1.19 (1.12–1.27)

 

1.19 (1.01–1.40)

1.26 (1.08–1.47)

 

0.82 (0.63–1.08)

1.39 (1.14–1.69)

 

 Model 2

1.02 (0.93–1.11)

1.09 (1.01–1.18)

 

1.08 (0.97–1.20)

1.11 (1.01–1.23)

 

1.04 (0.87–1.23)

1.03 (.88–1.22)

 

0.68 (0.52–0.90)

1.07 (0.87–1.33)

 

 Model 3

1.01 (0.93–1.10)

1.08 (0.99–1.17)

 

1.08 (0.97–1.20)

1.11 (1.00–1.22)

 

1.03 (0.87–1.23)

1.02 (.86–1.20)

 

0.68 (0.52–0.89)

1.05 (0.85–1.31)

 

 Model 4

1.01 (0.92–1.10)

1.08 (0.99–1.17)

 

1.09 (0.97–1.21)

1.11 (1.00–1.22)

 

1.01 (0.85–1.21)

1.01 (.86–1.20)

 

0.67 (0.50–0.89)

1.08 (0.86–1.34)

 

(3) Aged >60 yearsf (n = 5945)

  

328

  

224

  

58

  

46

 Model 1

0.90 (0.84–0.96)

0.96 (0.90–1.02)

 

0.90 (0.83–0.97)

0.95 (0.88–1.02)

 

0.92 (0.79–1.06)

0.98 (.85–1.12)

 

0.91 (0.77–1.07)

0.98 (0.84–1.15)

 

 Model 2

0.94 (0.88–0.99)

0.98 (0.92–1.04)

 

0.93 (0.86–1.01)

0.97 (0.90–1.05)

 

0.94 (0.81–1.10)

0.99 (.86–1.14)

 

0.94 (0.79–1.11)

1.00 (0.85–1.18)

 

 Model 3

0.92 (0.86–0.99)

0.96 (0.90–1.03)

 

0.92 (0.84–0.99)

0.95 (0.88–1.02)

 

0.94 (0.81–1.09)

0.98 (.85–1.14)

 

0.94 (0.79–1.11)

1.00 (0.85–1.19)

 

 Model 4

0.92 (0.85–0.98)

0.96 (0.90–1.02)

 

0.91 (0.83–0.98)

0.94 (0.87–1.02)

 

0.94 (0.81–1.10)

0.99 (.86–1.16)

 

0.92 (0.77–1.10)

0.99 (0.83–1.17)

 
  1. HUNT 1 Helse Undersøkelse Nord-Trøndelag (1984–1986), HUNT 2 Helse Undersøkelse Nord-Trøndelag (1995–1997)
  2. aNumber of dementia cases
  3. bModel 1: systolic blood pressure
  4. cModel 2: systolic blood pressure, age, sex, education
  5. dModel 3: systolic blood pressure, age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, pulse
  6. eModel 4: systolic blood pressure, age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status, physical activity, blood pressure medication, alcohol use
  7. fAge when examined in HUNT 1
  8. g​p-value <0.05
  9. The bold text represents p-value <=.05