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Table 2 Multiple logistic regression analyses on the association of systolic blood pressure and dementia

From: Association between blood pressure and Alzheimer disease measured up to 27 years prior to diagnosis: the HUNT Study

  All-cause dementia Alzheimer disease (AD) Vascular dementia (VaD) Mixed AD/VaD
OR (95% CI) NCa OR (95% CI) NCa OR (95% CI) NCa OR (95% CI) NCa
(1) Study sample (n = 24,638) HUNT 1 HUNT 2 579 HUNT 1 HUNT 2 383 HUNT 1 HUNT 2 118 HUNT 1 HUNT 2 78
 Model 1b 1.16 (1.12–1.20) g 1.16 (1.12–1.19)   1.15 (1.10–1.20) 1.14 (1.10–1.19)   1.18 (1.10–1.28) 1.19 (1.10–1.27)   1.15 (1.04–1.26) 1.18 (1.08–1.29)  
 Model 2c 0.94 (0.89–0.99) 1.03 (0.98–1.09)   0.95 (0.91–1.02) 1.04 (0.98–1.10)   0.96 (0.86–1.07) 1.02 (.92–1.14)   0.83 (0.72–0.96) 1.04 (0.92–1.18)  
 Model 3d 0.93 (0.88–0.98) 1.01 (0.96–1.06)   0.94 (0.88–1.01) 1.01 (0.95–1.07)   0.96 (0.85–1.07) 1.01 (.90–1.12)   0.82 (0.71–0.95) 1.03 (0.90–1.18)  
 Model 4e 0.92 (0.87–0.97) 1.01 (0.96–1.07)   0.94 (0.88–1.00) 1.01 (0.95–1.07)   0.95 (0.84–1.06) 1.01 (.90–1.13)   0.82 (0.71–0.95) 1.04 (0.91–1.18)  
(2) Aged <60 yearsf (n = 18,693)    251    159    60    32
 Model 1 1.21 (1.15–1.28) 1.19 (1.13–1.25)   1.21 (1.13–1.30) 1.19 (1.12–1.27)   1.19 (1.01–1.40) 1.26 (1.08–1.47)   0.82 (0.63–1.08) 1.39 (1.14–1.69)  
 Model 2 1.02 (0.93–1.11) 1.09 (1.01–1.18)   1.08 (0.97–1.20) 1.11 (1.01–1.23)   1.04 (0.87–1.23) 1.03 (.88–1.22)   0.68 (0.52–0.90) 1.07 (0.87–1.33)  
 Model 3 1.01 (0.93–1.10) 1.08 (0.99–1.17)   1.08 (0.97–1.20) 1.11 (1.00–1.22)   1.03 (0.87–1.23) 1.02 (.86–1.20)   0.68 (0.52–0.89) 1.05 (0.85–1.31)  
 Model 4 1.01 (0.92–1.10) 1.08 (0.99–1.17)   1.09 (0.97–1.21) 1.11 (1.00–1.22)   1.01 (0.85–1.21) 1.01 (.86–1.20)   0.67 (0.50–0.89) 1.08 (0.86–1.34)  
(3) Aged >60 yearsf (n = 5945)    328    224    58    46
 Model 1 0.90 (0.84–0.96) 0.96 (0.90–1.02)   0.90 (0.83–0.97) 0.95 (0.88–1.02)   0.92 (0.79–1.06) 0.98 (.85–1.12)   0.91 (0.77–1.07) 0.98 (0.84–1.15)  
 Model 2 0.94 (0.88–0.99) 0.98 (0.92–1.04)   0.93 (0.86–1.01) 0.97 (0.90–1.05)   0.94 (0.81–1.10) 0.99 (.86–1.14)   0.94 (0.79–1.11) 1.00 (0.85–1.18)  
 Model 3 0.92 (0.86–0.99) 0.96 (0.90–1.03)   0.92 (0.84–0.99) 0.95 (0.88–1.02)   0.94 (0.81–1.09) 0.98 (.85–1.14)   0.94 (0.79–1.11) 1.00 (0.85–1.19)  
 Model 4 0.92 (0.85–0.98) 0.96 (0.90–1.02)   0.91 (0.83–0.98) 0.94 (0.87–1.02)   0.94 (0.81–1.10) 0.99 (.86–1.16)   0.92 (0.77–1.10) 0.99 (0.83–1.17)  
  1. HUNT 1 Helse Undersøkelse Nord-Trøndelag (1984–1986), HUNT 2 Helse Undersøkelse Nord-Trøndelag (1995–1997)
  2. aNumber of dementia cases
  3. bModel 1: systolic blood pressure
  4. cModel 2: systolic blood pressure, age, sex, education
  5. dModel 3: systolic blood pressure, age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, pulse
  6. eModel 4: systolic blood pressure, age, sex, education, cholesterol, nonfasting blood glucose, glomerular filtration rate, body mass index, waist-to-hip ratio, pulse, history of myocardial infarction, diabetes mellitus, angina, stroke, smoking, subjective health status, physical activity, blood pressure medication, alcohol use
  7. fAge when examined in HUNT 1
  8. g​p-value <0.05
  9. The bold text represents p-value <=.05
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Alzheimer's Research & Therapy

ISSN: 1758-9193