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Table 3 Results of ROC analyses for standardised uptake value ratio and cerebrospinal fluid markers

From: Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer’s disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database

  SUVr (pons) SUVr (crb) SUVr (comp) 1–42 Tau p-Tau181 p-Tau/Aβ
Cross-sectional cohort
 Optimal cut-off 0.91 1.22 0.91 157 69 32 0.18
 AUC 0.88 0.84 0.88 0.83 0.85 0.79 0.85
 Acc 85% 81% 85% 80% 75% 70% 77%
 Se 85% 83% 87% 87% 90% 85% 93%
 Sp 85% 79% 83% 75% 63% 59% 65%
Longitudinal cohort
 Optimal cut-off 0.91 1.24 0.89 171 88 45 0.27
 AUC 0.85 0.84 0.86 0.85 0.81 0.80 0.85
 Acc 82% 82% 84% 79% 79% 75% 82%
 Se 83% 84% 88% 90% 68% 71% 83%
 Sp 82% 81% 81% 70% 87% 79% 81%
 PPV 43% 44% 42% 35% 44% 43% 44%
 NPV 94% 95% 96% 96% 90% 91% 94%
 RR 7.2 8.1 9.6 8.0 4.6 4.6 7.6
  1. Abbreviations: Acc Accuracy, Se Sensitivity (positivity rate among patients with Alzheimer’s disease), Sp Specificity (negativity rate among control subjects/normal patients), PPV Positive predictive value, NPV Negative predictive value, RR Risk ratio for evolving to Alzheimer’s disease, Pons Pontine, crb Cerebellar, comp Composite