Fig. 4

Evolution of cognitive scores in the longitudinal cohort (patients with significant memory complaint/mild cognitive impairment [MCI]) according to baseline composite standardised uptake value ratio (SUVr). From left to right: Mean annual change in Mini Mental State Examination (MMSE), Clinical Dementia Rating (CDR) and Alzheimer’s Disease Assessment Scale–Cognitive Subscale (ADAS-cog). a Scatterplot in which marker colour refers to last known status. The vertical dashed grey line indicates the optimal SUVr cut-off. The black dashed curve stands for the quadratic regression. ρ Spearman’s rank correlation. b Score distribution according to positron emission tomography (PET) profile based on composite SUVr (cut-off 0.89). Boxes represent mean with 95% CI. Whiskers represent mean ± 1.5 SD. ns Not significant, NL Normal, AD Alzheimer’s disease