Skip to main content

Table 4 Mean receptor densities in the caudate nucleus of control subjects and patients with progressive supranuclear palsy

From: Multireceptor fingerprints in progressive supranuclear palsy

  Progressive supranuclear palsy vs. control subjects Progressive supranuclear palsy, frontal vs. nonfrontal presentation Progressive supranuclear palsy, mild vs. severe tau pathology
Receptor Control subjects Patients p Value Frontal Nonfrontal p Value Mild Severe p Value
AMPA 607 (108) 583 (228) 0.749 477 (248) 665 (184) 0.102 631 (220) 503 (238) 0.290
Kainate 879 (61) 800 (73) 0.007 783 (70) 813 (76) 0.426 793 (68) 812 (85) 0.628
NMDA 1216 (42) 1218 (115) 0.951 1210 (122) 1224 (118) 0.823 1251 (116) 1163 (99) 0.413
mGlu2/3 9295 (625) 9416 (1455) 0.799 8735 (1746) 9945 (980) 0.100 9502 (1272) 9272 (1843) 0.771
GABAA 1273 (164) 1091 (203) 0.021 986 (214) 1173 (160) 0.065 1133 (178) 1021 (239) 0.304
GABAB 2477 (299) 2684 (397) 0.155 2529 (402) 2805 (370) 0.177 2788 (382) 2511 (389) 0.184
BZ 1684 (136) 1458 (330) 0.023 1463 (422) 1454 (266) 0.956 1635 (284) 1163 (121) 0.002
pBZ 1759 (89) 2050 (347) 0.005 2127 (392) 1989 (317) 0.450 2154 (365) 1876 (251) 0.123
M1 1174 (35) 922 (379) 0.018 968 (351) 886 (418) 0.686 904 (412) 952 (353) 0.815
M2 567 (56) 497 (127) 0.063 467 (140) 520 (119) 0.422 501 (158) 490 (54) 0.049
M3 1755 (36) 1740 (255) 0.829 1753 (309) 1731 (223) 0.869 1751 (299) 1723 (183) 0.843
nACh 200 (42) 105 (43) <0.001 97 (30) 111 (52) 0.522 119 (42) 82 (38) 0.094
α1 339 (28) 338 (53) 0.945 314 (51) 356 (50) 0.123 331 (47) 349 (65) 0.543
α2 467 (65) 510 (92) 0.199 502 (98) 516 (94) 0.767 498 (91) 531 (99) 0.500
5-HT1A 129 (16) 135 (27) 0.543 139 (28) 132 (28) 0.646 139 (33) 128 (12) 0.428
5-HT2 1069 (100) 976 (142) 0.074 976 (138) 976 (153) 0.996 1048 (105) 856 (115) 0.004
D1 291 (8) 332 (49) 0.010 341 (30) 326 (61) 0.456 349 (53) 305 (25) 0.085
D2 885 (50) 818 (103) 0.057 765 (108) 860 (82) 0.066 845 (99) 774 (102) 0.188
A1 1522 (239) 1952 (288) <0.001 1966 (327) 1942 (274) 0.786 1938 (349) 1977 (167) 0.806
A2A 1814 (195) 2105 (327) 0.014 2112 (409) 2100 (273) 0.944 2093 (391) 2124 (212) 0.863
  1. Abbreviations: A 1 Adenosine receptor type 1, A 2A Adenosine receptor type 2A, α 1 Adrenoceptor type 1, α 2 Adrenoceptor type 2, AMPA α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, BZ γ-Aminobutyric acid type A-associated benzodiazepine-binding site, D1 Dopamine receptor type 1, D2 Dopamine receptor type 2, GABA A γ-Aminobutyric acid receptor type A, GABA B γ-Aminobutyric acid receptor type B, 5-HT 1A Serotonin receptor type 1A, 5-HT 2 Serotonin receptor type 2, M 1 , M 2 , M 3 Muscarinic cholinergic receptor types 1, 2, 3, mGlu2/3 Metabotropic glutamate receptor type 2/3, nACh Nicotinic cholinergic receptor of the α42 type, NMDA N-methyl-d-aspartate, pBZ Peripheral benzodiazepine receptor
  2. Absolute densities (SD) in femtomoles per milligram of protein as well as p values for the post hoc tests (significant values are highlighted in boldface type) are provided for each receptor type