Table 4 Mean receptor densities in the caudate nucleus of control subjects and patients with progressive supranuclear palsy
From: Multireceptor fingerprints in progressive supranuclear palsy
| Â | Progressive supranuclear palsy vs. control subjects | Progressive supranuclear palsy, frontal vs. nonfrontal presentation | Progressive supranuclear palsy, mild vs. severe tau pathology | ||||||
|---|---|---|---|---|---|---|---|---|---|
Receptor | Control subjects | Patients | p Value | Frontal | Nonfrontal | p Value | Mild | Severe | p Value |
AMPA | 607 (108) | 583 (228) | 0.749 | 477 (248) | 665 (184) | 0.102 | 631 (220) | 503 (238) | 0.290 |
Kainate | 879 (61) | 800 (73) | 0.007 | 783 (70) | 813 (76) | 0.426 | 793 (68) | 812 (85) | 0.628 |
NMDA | 1216 (42) | 1218 (115) | 0.951 | 1210 (122) | 1224 (118) | 0.823 | 1251 (116) | 1163 (99) | 0.413 |
mGlu2/3 | 9295 (625) | 9416 (1455) | 0.799 | 8735 (1746) | 9945 (980) | 0.100 | 9502 (1272) | 9272 (1843) | 0.771 |
GABAA | 1273 (164) | 1091 (203) | 0.021 | 986 (214) | 1173 (160) | 0.065 | 1133 (178) | 1021 (239) | 0.304 |
GABAB | 2477 (299) | 2684 (397) | 0.155 | 2529 (402) | 2805 (370) | 0.177 | 2788 (382) | 2511 (389) | 0.184 |
BZ | 1684 (136) | 1458 (330) | 0.023 | 1463 (422) | 1454 (266) | 0.956 | 1635 (284) | 1163 (121) | 0.002 |
pBZ | 1759 (89) | 2050 (347) | 0.005 | 2127 (392) | 1989 (317) | 0.450 | 2154 (365) | 1876 (251) | 0.123 |
M1 | 1174 (35) | 922 (379) | 0.018 | 968 (351) | 886 (418) | 0.686 | 904 (412) | 952 (353) | 0.815 |
M2 | 567 (56) | 497 (127) | 0.063 | 467 (140) | 520 (119) | 0.422 | 501 (158) | 490 (54) | 0.049 |
M3 | 1755 (36) | 1740 (255) | 0.829 | 1753 (309) | 1731 (223) | 0.869 | 1751 (299) | 1723 (183) | 0.843 |
nACh | 200 (42) | 105 (43) | <0.001 | 97 (30) | 111 (52) | 0.522 | 119 (42) | 82 (38) | 0.094 |
α1 | 339 (28) | 338 (53) | 0.945 | 314 (51) | 356 (50) | 0.123 | 331 (47) | 349 (65) | 0.543 |
α2 | 467 (65) | 510 (92) | 0.199 | 502 (98) | 516 (94) | 0.767 | 498 (91) | 531 (99) | 0.500 |
5-HT1A | 129 (16) | 135 (27) | 0.543 | 139 (28) | 132 (28) | 0.646 | 139 (33) | 128 (12) | 0.428 |
5-HT2 | 1069 (100) | 976 (142) | 0.074 | 976 (138) | 976 (153) | 0.996 | 1048 (105) | 856 (115) | 0.004 |
D1 | 291 (8) | 332 (49) | 0.010 | 341 (30) | 326 (61) | 0.456 | 349 (53) | 305 (25) | 0.085 |
D2 | 885 (50) | 818 (103) | 0.057 | 765 (108) | 860 (82) | 0.066 | 845 (99) | 774 (102) | 0.188 |
A1 | 1522 (239) | 1952 (288) | <0.001 | 1966 (327) | 1942 (274) | 0.786 | 1938 (349) | 1977 (167) | 0.806 |
A2A | 1814 (195) | 2105 (327) | 0.014 | 2112 (409) | 2100 (273) | 0.944 | 2093 (391) | 2124 (212) | 0.863 |