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Table 3 Detailed clinical features of patients with progressive supranuclear palsy

From: Multireceptor fingerprints in progressive supranuclear palsy

Patient Age at onset (years) Age at death (years) NINDS-SPSP criteria during life Frontal presentation Family history Relevant medication in the last 3 months of life Brain weight (g) Tau pathology area 24' Tau pathology caudate
1a 71 73 Probable Nonfrontal Negative Clonazepam, temazepam, piracetam 1398 Grade 3 Grade 2
2 66 76 Probable Frontal Negative Oxybutynin, acetylcysteine, thiopental, pancuronium 1060 Grade 3 Grade 2
3 63 68 Probable Nonfrontal Positive Temazepam, oxybutynin 1405 Grade 3 Grade 4
4 70 79 Possible Frontal Positive Tolterodine 1069 Grade 2 Grade 2
5 51 60 Probable Frontal Negative Temazepam 1256 Grade 3 Grade 4
6a 74 80 Possible Nonfrontal Negative Thiopental, pancuronium 1100 Grade 2 Grade 1
7 66 75 Possible Frontal Negative Levomeprazine 1253 Grade 3 Grade 1
8 54 64 Possible Frontal Positive Amantadine 1290 Grade 3 Grade 1
9 79 85 Possible Nonfrontal Negative Oxazepam, nitrazepam, acetylcysteine 1175 Grade 2 Grade 2
10 68 79 Probable Nonfrontal Negative Amitriptyline 922 Grade 2 Grade 1
11 60 72 Possible Nonfrontal Positive Levodopa/carbidopa, amitriptyline 1045 Grade 2 Grade 2
12 60 67 Probable Frontal Positive Levodopa/carbidopa, lormetazepam, nortriptyline 1013 Grade 4 Grade 2
13 62 70 Probable Nonfrontal Negative Amantadine, temazepam, diazepam, amitriptyline 1160 Grade 2 Grade 3
14a 79 85 Possible Nonfrontal Negative Alprazolam, tamsulosin, thiopental, pancuronium 1305 Grade 3 Grade 3
15 67 72 Possible Nonfrontal Positive Levodopa/carbidopa 1525 Grade 2 Grade 4
16 61 69 Probable Frontal Positive Midazolam, clozapine 1270 Grade 3 Grade 3
  1. NINDS-SPSP National Institute of Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy
  2. aPatients who underwent euthanasia by sodium thiopental and pancuronium bromide