Fig. 1

Receptor fingerprints of progressive supranuclear palsy (PSP)-related receptor density alterations in the caudate nucleus (a–c) and area 24′ (d–f). Polar plots showing the mean relative changes (in percent) in binding density of tissue obtained from the caudate nucleus (a) and area 24′ (d) of patients with PSP (mean value coded by green lines, SD given by transparent surface) with respect to control subjects (0%, in black). Polar plots showing the mean relative changes (in percent) in binding density of tissue obtained from the caudate nucleus (b) and area 24′ (e) of patients with PSP with frontal presentation (mean value coded by red lines, SD given by red transparent surface) or with nonfrontal presentation (mean value coded by blue lines, SD given by blue transparent surface) with respect to control subjects (0%, in black). Polar plots showing the mean relative changes (in percent) in binding density of tissue obtained from the caudate nucleus (c) and area 24′ (f) of patients with PSP with no to mild tau pathology (mean value coded by turquoise lines, SD given by turquoise transparent surface) or with moderate to severe tau pathology (mean value coded by pink lines, SD given by pink transparent surface) with respect to control subjects (0%, in black). Colored asterisks highlight receptors that were significantly altered in a given PSP cohort compared with control subjects. Hashtags indicate receptors significantly different when comparing PSP cases with no to mild tau pathology and PSP cases with moderate to severe tau pathology. α ₄ /β ₂ Nicotinic cholinergic receptors of the α₄/β₂ type, BZ γ-Aminobutyric acid receptor type A-associated benzodiazepine binding sites, pBZ Peripheral benzodiazepine receptors