Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

Fig. 5

Antibody isotypes of anti-Aβ antibodies produced in the Rhesus monkey. a The humoral immune response generated anti-Aβ IgG, - IgM, and - IgA antibodies in the immunized monkeys. Plasma samples had been used in a 1:1000 dilution. b Binding of the different antibody isotypes to truncated Aβ x–42 peptides was tested from plasma after six immunizations (dilution 1:500). c, d Anti-Aβ42 IgG, -IgA, and -IgM antibody isotype responses were compared for different time points (3x yellow bars, 4x orange bars, 6x light green bars, and three months rest purple bars) in male C and female D Rhesus macaques. Results are shown in box & whiskers graphs from minimum to maximum values. Median levels were indicated with the horizontal line, the Standard Error Mean (SEM) is shown for all columns above and below the boxes

Back to article page