Fig. 5

Antibody isotypes of anti-Aβ antibodies produced in the Rhesus monkey. a The humoral immune response generated anti-Aβ IgG, - IgM, and - IgA antibodies in the immunized monkeys. Plasma samples had been used in a 1:1000 dilution. b Binding of the different antibody isotypes to truncated Aβ _x–42 peptides was tested from plasma after six immunizations (dilution 1:500). c, d Anti-Aβ42 IgG, -IgA, and -IgM antibody isotype responses were compared for different time points (3x yellow bars, 4x orange bars, 6x light green bars, and three months rest purple bars) in male C and female D Rhesus macaques. Results are shown in box & whiskers graphs from minimum to maximum values. Median levels were indicated with the horizontal line, the Standard Error Mean (SEM) is shown for all columns above and below the boxes