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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

Fig. 4

Antibody titers in the rhesus monkeys immunized six times. Serial dilutions of plasma samples from the six immunizations are shown. Immunization time points were tested for binding to amyloid-β peptide 1–42 (Aβ42) peptide in two-step enzyme-linked immunosorbent assays. a Antibody titers for anti-Aβ42 antibodies of the immunoglobulin A (IgA) isotype. b Antibody titers for antibodies of the IgG isotype. For comparison with antibody titers prior to the immunizations and to antibody titers following the second immunizations, these titers were included in the graph of the IgG titer analysis (red and green lines). Individual animals are shown with specific symbols as indicated on the figure. Animals receiving the high-dose (16 μg of DNA per immunization) and low-dose (8 μg of DNA/immunization) immunizations are indicated by HD and LD, respectively. c Comparison of IgG and IgA antibody titers in the immunized monkeys. Mean, SD, and SEM values are given in the table below the graph

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