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Fig. 10 | Alzheimer's Research & Therapy

Fig. 10

From: Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

Fig. 10

Interleukin (IL)-17 and IL-4 Enzyme-Linked ImmunoSpot (ELISPOT) assays, as well as interferon (IFN)-γ enzyme-linked immunosorbent assay (ELISA) from amyloid-β peptide 1–42 (Aβ42) peptide-restimulated peripheral blood mononuclear cell cultures of DNA Aβ42-immunized rhesus monkeys after a 3-month rest period. IL-17- and IL-4-secreting cells were analyzed in an ELISPOT assay (a–c). IFN-γ secretion was tested with a cytokine ELISA (d). The individual rhesus monkeys are indicated with numbers on the x-axis of all graphs. a–c The y-axis shows the number of cytokine-secreting cells (spots) per 106 cells. d The y-axis shows the amount of IFN-γ found (expressed in picograms per milliliter of culture supernatant)

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