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Table 1 Clinical and demographic data

From: Memory is preserved in older adults taking AT1 receptor blockers

Characteristics

Total (n = 1586)

Normotensive (n = 782)

HTN-ARBs (n = 183)

HTN-Other (n = 621)

F or χ2 value

p Value

Baseline clinical/demographic characteristics

      

 Age, years

73.1 (7.2)

71.9 (7.3)

73.3 (6.8)

74.6 (6.8)

25.737

<0.001

 Education, years

16.1 (2.8)

16.3 (2.7)

15.9 (3.2)

15.9 (2.8)

5.282

0.005

 Male sex, %

53.8%

50.6%

51.6%

58.4%

8.685

0.013

 APOE genotype, ε4 allele-positive, %

42.3%

43.4%

36.8%

42.5%

2.365

0.306

 MCI diagnosis, %

60.3%

59.8%

54.4%

62.7%

4.216

0.121

 BMI, kg/m2

27.1 (4.8)

26.4 (4.6)

28.0 (4.8)

27.6 (4.8)

14.844

<0.001

 Systolic BP, mmHg

134.1 (15.7)

130.9 (14.4)

138.5 (16.4)

136.7 (16.2)

32.318

<0.001

 Diastolic BP, mmHg

74.5 (9.4)

73.9 (8.9)

75.5 (9.7)

75.0 (9.8)

3.467

0.031

 Pulse pressure, mmHg

59.6 (14.2)

57.1 (13.1)

63.0 (15.5)

61.7 (14.6)

25.014

<0.001

Baseline vascular risk factors

 Cardiovascular disease

11.2%

3.7%

17.6%

18.8%

87.645

<0.001

 Dyslipidemia

46.2%

37.6%

59.3%

53.2%

48.249

<0.001

 Type 2 diabetes

8.6%

3.7%

23.1%

10.5%

75.236

<0.001

 Atrial fibrillation

3.3%

1.8%

3.3%

5.1%

12.293

0.002

 Carotid artery disease

0.6%

0.4%

0.5%

1.0%

1.888

0.389

 TIA/minor stroke

2.9%

1.3%

3.3%

4.8%

15.569

<0.001

3-Year follow-up blood pressure data

Total ( n  = 779)

Normotensive ( n  = 380)

HTN-ARBs ( n  = 89)

HTN-Other ( n  = 310)

  

 Systolic BP, mmHg

131.9 (16.9)

129.0 (15.8)

133.9 (16.2)

134.9 (17.7)

11.602

<0.001

 Diastolic BP, mmHg

72.6 (9.6)

72.0 (9.3)

74.0 (10.2)

73.0 (9.8)

1.843

0.159

 Pulse pressure, mmHg

59.3 (14.7)

56.9 (14.0)

59.9 (13.2)

61.9 (15.5)

10.203

< 0.001

  1. Abbreviations: APOE Apolipoprotein E, BMI Body mass index, BP Blood pressure, HTN-ARBs Participants who took angiotensin II receptor blockers, HTN-Other Participants who took other antihypertensive drugs that were not angiotensin II receptor blockers, MCI Mild cognitive impairment, TIA Transient ischemic attack
  2. Data are summarized as mean (SD), unless otherwise indicated
  3. Significant differences (p < 0.05) among medication groups are indicated by boldface type