From: Memory is preserved in older adults taking AT1 receptor blockers
Characteristics | Total (n = 1586) | Normotensive (n = 782) | HTN-ARBs (n = 183) | HTN-Other (n = 621) | F or χ2 value | p Value |
---|---|---|---|---|---|---|
Baseline clinical/demographic characteristics | ||||||
Age, years | 73.1 (7.2) | 71.9 (7.3) | 73.3 (6.8) | 74.6 (6.8) | 25.737 | <0.001 |
Education, years | 16.1 (2.8) | 16.3 (2.7) | 15.9 (3.2) | 15.9 (2.8) | 5.282 | 0.005 |
Male sex, % | 53.8% | 50.6% | 51.6% | 58.4% | 8.685 | 0.013 |
APOE genotype, ε4 allele-positive, % | 42.3% | 43.4% | 36.8% | 42.5% | 2.365 | 0.306 |
MCI diagnosis, % | 60.3% | 59.8% | 54.4% | 62.7% | 4.216 | 0.121 |
BMI, kg/m2 | 27.1 (4.8) | 26.4 (4.6) | 28.0 (4.8) | 27.6 (4.8) | 14.844 | <0.001 |
Systolic BP, mmHg | 134.1 (15.7) | 130.9 (14.4) | 138.5 (16.4) | 136.7 (16.2) | 32.318 | <0.001 |
Diastolic BP, mmHg | 74.5 (9.4) | 73.9 (8.9) | 75.5 (9.7) | 75.0 (9.8) | 3.467 | 0.031 |
Pulse pressure, mmHg | 59.6 (14.2) | 57.1 (13.1) | 63.0 (15.5) | 61.7 (14.6) | 25.014 | <0.001 |
Baseline vascular risk factors | ||||||
Cardiovascular disease | 11.2% | 3.7% | 17.6% | 18.8% | 87.645 | <0.001 |
Dyslipidemia | 46.2% | 37.6% | 59.3% | 53.2% | 48.249 | <0.001 |
Type 2 diabetes | 8.6% | 3.7% | 23.1% | 10.5% | 75.236 | <0.001 |
Atrial fibrillation | 3.3% | 1.8% | 3.3% | 5.1% | 12.293 | 0.002 |
Carotid artery disease | 0.6% | 0.4% | 0.5% | 1.0% | 1.888 | 0.389 |
TIA/minor stroke | 2.9% | 1.3% | 3.3% | 4.8% | 15.569 | <0.001 |
3-Year follow-up blood pressure data | Total ( n = 779) | Normotensive ( n = 380) | HTN-ARBs ( n = 89) | HTN-Other ( n = 310) | ||
Systolic BP, mmHg | 131.9 (16.9) | 129.0 (15.8) | 133.9 (16.2) | 134.9 (17.7) | 11.602 | <0.001 |
Diastolic BP, mmHg | 72.6 (9.6) | 72.0 (9.3) | 74.0 (10.2) | 73.0 (9.8) | 1.843 | 0.159 |
Pulse pressure, mmHg | 59.3 (14.7) | 56.9 (14.0) | 59.9 (13.2) | 61.9 (15.5) | 10.203 | < 0.001 |