| |
Group (total, n = 353)
| |
|---|
|
Basic characteristic
|
PiB– (n = 253)
|
PiB+ (n = 100)
|
P valuea
|
|
Global PiB deposition, mean ± SEM
|
1.11 ± 0.004
|
1.91 ± 0.038
|
<0.001
|
|
Clinical diagnosis, N/M/D
|
187/50/16
|
28/29/43
|
<0.001†
|
|
Gender, male/female
|
95/158
|
38/62
|
>0.05†
|
|
Age (years), mean ± SEM
|
69.94 ± 0.5
|
73.00 ± 0.7
|
<0.001
|
|
CDR, mean ± SEM
|
0.15 ± 0.02
|
0.5 ± 0.04
|
<0.001
|
|
MMSE z score,b mean ± SEM
|
–0.13 ± 0.07
|
–1.91 ± 0.20
|
<0.001
|
|
Education, mean ± SEM
|
10.65 ± 0.3
|
10.82 ± 0.5
|
>0.05
|
|
ApoE4-positive, n/N (%)
|
39/253 (15%)
|
57/100 (57%)
|
<0.001†
|
- Details of clinical diagnosis and pathological states (CDR score, MMSE z score, and global PiB deposition (SUVR)) of each subject are shown in Additional file 3
-
PiB Pittsburgh-compound B, SUVR standardized uptake value ratio, – or + PiB-PET positivity, MMSE Mini-Mental State Examination, CDR Clinical Dementia Rating, ApoE apolipoprotein E, SEM standard error of mean, n number of subjects, N/M/D cognitively normal/mild impairment/dementia
-
a
P value, significance by unpaired t-test except for clinical diagnosis, gender, and ApoE
-
bA revised value of the MMSE score with consideration for age, gender, and education level
-
†Pearson’s chi-square test
