Fig. 4

MPP-Aβs reflect the pathological load of Aβ in the brain. a Intergroup differences of MPP-Aβ levels using xMAP technology (*P < 0.05 and **P < 0.01, unpaired t test; ^§ P < 0.05, ^§§ P < 0.01, and ^§§§ P < 0.001, ANOVA followed by Tukey’s multiple comparison test; ^# P < 0.10, unpaired t test, trend toward significance; CN–, n = 187, CN+, n = 28, MCI–, n = 50, MCI+, n = 29, ADD–, n = 16, ADD+, n = 43; total subjects n = 353). b Correlation of global PiB deposition (SUVR) and MPP-Aβs (n = 353, ***P < 0.0001; Pearson’s correlation). c, d MPP-Aβ42, MPP-Aβ40, and MPP-Aβ42/40 levels in ND– (n = 237; CN– and MCI–), ND+ (n = 57; CN+ and MCI+), PiB– (n = 253; CN–, MCI–, and ADD–), and PiB+ (n = 100; CN+, MCI+, and ADD+) (**P < 0.01, and ***P < 0.001, unpaired t test). Aβ β-amyloid, MPP mixture of protease inhibitors and phosphatase inhibitors, MCI mild cognitive impairment, ADD Alzheimer’s disease dementia, CN cognitively normal, SUVR standard uptake value ratio, PiB Pittsburgh compound B, – or + PiB negativity or positivity, ND nondemented