Fig. 3

POC for the effect of MPP on distinction between subjects. a Intergroup differences in the plasma Aβ concentration with or without 4% MPP solution using xMAP technology. MCI+ and ADD+ subjects show significantly decreased levels of MPP-Aβ42 and MPP-Aβ42/40 ratio compared with CN– subjects (**P < 0.01 and ***P < 0.001 respectively; ANOVA followed by Tukey’s multiple comparison test; CN–, n = 20; MCI+, n = 12; ADD+, n = 23; total subjects, n = 55). b Correlation of global PiB deposition (SUVR) and MPP-Aβs. MPP-Aβ42 level (***P < 0.001, r = –0.47; Pearson’s correlation) and MPP-Aβ42/40 ratio (**P < 0.01, r = –0.39; Pearson’s correlation) are correlated with global PiB deposition (SUVR). Aβ β-amyloid, MPP mixture of protease inhibitors and phosphatase inhibitors, MCI mild cognitive impairment, ADD Alzheimer’s disease dementia, CN cognitively normal, SUVR standard uptake value ratio, PiB Pittsburgh compound B, – or + PiB negativity or positivity