Cognitive profile in prodromal dementia with Lewy bodies

Table 1 Demographic and clinical characteristics of patients and healthy control subjects

Characteristic	Patients with DLB	HCs	p Value
n	37	29
Age, years^a	67.19 (8.64)	68.79 (7.94)	NS
Education, years^a	11.97 (4.14)	13.18 (3.08)	NS
Sex, M/F	18/19	15/14	NS
Handedness, R/L	35/2	27/2	NS
IADL score^a,b	3.75 (0.50)	4 (0)	0.02
ADL score^a,c	5.89 (0.39)	6 (0)	NS
MCI single/multiple domains
Amnestic	0/18	–	–
Non-amnestic	10/9	–	–
Parkinsonism, n (%)^d
Rigidity	28/37 (76)	0/23	<0.001
Akinesia	22/37 (59)	1/24	<0.001
Tremor at rest	10/37 (27)	1/24	0.02
Hallucinations, n (%)^d	24/37 (65)	1/24	<0.001
Fluctuations, n (%)^d,e	28/37 (76)	0/24	<0.001
CSF^f,g
Aβ₄₂	902.6 (265.1, 2)	–	–
p-Tau	43.4 (12.2, 2)	–	–
Tau	306.1 (264.1, 1)	–	–
Hippocampal atrophy, 0/1/2/3/4^h
Left hippocampus	17/8/9/2/0	14/8/2/0/0	NS
Right hippocampus	15/10/11/0/0	11/11/2/0/0	NS

Abbreviations: Aβ ₄₂ Amyloid-β 42, ADL Activities of daily living, CSF Cerebrospinal fluid, DLB Dementia with Lewy bodies, HC Healthy control subjects, IADL Instrumental activities of daily living, MCI Mild cognitive impairment, NS Not significant, p-Tau Phosphorylated tau
^aValues are mean (SD)
^bAccording to [32, 33]
^cAccording to [34]
^dData partially missing for six HCs
^eAccording to the Mayo Fluctuations Questionnaire [69]
^fData missing for ten patients
^gValues are mean (SD, patients with abnormal values)
^hAccording to [35]; one patient with DLB and five HCs did not have magnetic resonance imaging scans

ISSN: 1758-9193