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Table 1 Demographic and clinical characteristics of patients and healthy control subjects

From: Cognitive profile in prodromal dementia with Lewy bodies

Characteristic Patients with DLB HCs p Value
n 37 29  
Age, yearsa 67.19 (8.64) 68.79 (7.94) NS
Education, yearsa 11.97 (4.14) 13.18 (3.08) NS
Sex, M/F 18/19 15/14 NS
Handedness, R/L 35/2 27/2 NS
IADL scorea,b 3.75 (0.50) 4 (0) 0.02
ADL scorea,c 5.89 (0.39) 6 (0) NS
MCI single/multiple domains
 Amnestic 0/18
 Non-amnestic 10/9
Parkinsonism, n (%)d
 Rigidity 28/37 (76) 0/23 <0.001
 Akinesia 22/37 (59) 1/24 <0.001
 Tremor at rest 10/37 (27) 1/24 0.02
Hallucinations, n (%)d 24/37 (65) 1/24 <0.001
Fluctuations, n (%)d,e 28/37 (76) 0/24 <0.001
CSFf,g
 Aβ42 902.6 (265.1, 2)
 p-Tau 43.4 (12.2, 2)
 Tau 306.1 (264.1, 1)
Hippocampal atrophy, 0/1/2/3/4h
 Left hippocampus 17/8/9/2/0 14/8/2/0/0 NS
 Right hippocampus 15/10/11/0/0 11/11/2/0/0 NS
  1. Abbreviations: Aβ 42 Amyloid-β 42, ADL Activities of daily living, CSF Cerebrospinal fluid, DLB Dementia with Lewy bodies, HC Healthy control subjects, IADL Instrumental activities of daily living, MCI Mild cognitive impairment, NS Not significant, p-Tau Phosphorylated tau
  2. aValues are mean (SD)
  3. bAccording to [32, 33]
  4. cAccording to [34]
  5. dData partially missing for six HCs
  6. eAccording to the Mayo Fluctuations Questionnaire [69]
  7. fData missing for ten patients
  8. gValues are mean (SD, patients with abnormal values)
  9. hAccording to [35]; one patient with DLB and five HCs did not have magnetic resonance imaging scans