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Table 4 HRs (95% CIs) of the Australian National University Alzheimer’s Disease Risk Index and explained variance-weighted genetic risk scores upon cognitive transition

From: Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years

Transition MCI and dementia MCI-TB
ANU-ADRIa EV-GRSb ANU-ADRIa EV-GRSb
CN to MCI 1.07 (1.04–1.10)c 1.05 (0.86–1.29) 1.07 (1.04–1.09)c 1.03 (0.87–1.21)
CN to dementia 0.61 (0.33–1.13) 4.19 (1.72–10.2)c   
CN to death 1.03 (0.94–1.12) 0.70 (0.27–1.84) 1.02 (0.98–1.06) 0.89 (0.69–1.16)
MCI to CN 0.85 (0.11–6.79) 0.95 (0–181.21) 0.71 (0.50–1.00) 0.44 (0.12–1.54)
MCI to dementia 1.02 (0.94–1.10) 1.19 (0.76–1.85)   
MCI to death 0.96 (0.83–1.11) 0.87 (0.29–2.63) 1.05 (0.98–1.12) 1.05 (0.65–1.71)
Dementia to death 0.99 (0.90–1.09) 0.78 (0.51–1.19)   
  1. Abbreviations: ANU-ADRI Australian National University Alzheimer’s Disease Risk Index, EV-GRS Explained variance-weighted genetic risk score, CN Cognitively normal, MCI/dementia Mild cognitive impairment or dementia, MCI-TB Test-based mild cognitive impairment
  2. All estimates are derived from models adjusting for the ANU-ADRI and EV-GRS
  3. aPer unitary increase in ANU-ADRI
  4. bPer SD increase in EV-GRS
  5. c p < 0.05