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Table 3 Associations between the Australian National University Alzheimer’s Disease Risk Index and explained variance-weighted genetic risk scores and cognitive impairment at waves 1–4

From: Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years

  MCI/dementia MCI-TB
ANU-ADRIa, HR (95% CI) 1.06 (1.03–1.09)b 1.04 (1.02–1.50)b
EV-GRSc, HR (95% CI) 1.14 (0.98–1.33) 1.04 (0.96–1.12)
C-index (SE) 0.61 (0.03) 0.56 (0.01)
 ANU-ADRI 0.60 (0.05) 0.56 (0.02)
 EV-GRS 0.53 (0.05) 0.51 (0.02)
  1. Abbreviations: ANU-ADRI Australian National University Alzheimer’s Disease Risk Index; C-index Concordance index; EV-GRS Explained variance-weighted genetic risk score
  2. All estimates are derived from models adjusting for ANU-ADRI and EV-GRS
  3. aPer unitary increase in ANU-ADRI
  4. b p < .001
  5. cPer SD increase in EV-GRS