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Table 1 Characteristics of Personality and Total Health Through Life project cohort for waves 1–4

From: Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years

 

Wave 1, estimate ± SD

Wave 2, estimate ± SD

Wave 3, estimate ± SD

Wave 4, estimate ± SD

n

2078

1798

1596

1337

Age, years

63 ± 1.5

67 ± 1.5

71 ± 1.5

75 ± 1.5

Female sex, n (%)

1009 (48.5)

870 (48.3)

775 (48.6)

651 (48.7)

Education

14 ± 2.8

 Wave 1 completers

12.7 ± 3.0

 Wave 2 completers

13.1 ± 2.7

 Wave 3 completers

13.5 ± 2.7

 Wave 4 completers

14.2 ± 2.6

Immediate recall

7.2 ± 2.3

7 ± 2.2

6.7 ± 2.2

5.4 ± 1.9

Digit Span Backward

4.9 ± 2.2

5.1 ± 2.2

5.1 ± 2.2

5.3 ± 2.2

Spot-the-Word test

52.0 ± 6.0

53 ± 5.3

53 ± 5.1

54 ± 5

SDMT

50.0 ± 9.7

50 ± 9.2

48 ± 9.2

46 ± 9.5

ANU-ADRI

9.4 ± 5.9

EV-GRS

1.6 ± 0.4

Cognitive status, n (%)

 MCI

23 (1.1)

28 (1.6)

35 (2.2)

103 (7.7)

 Dementia

0 (0)

0 (0)

7 (0.44)

37 (2.7)

 MCI-TB

384 (18.4)

373 (20.7)

347 (21.7)

261 (19.5)

Attrition, n (%)

 Death

57 (2.7)

54 (2.5)

94 (5.8)

 Dropout

280 (13.5)

167 (9.3)

329 (20.6)

  1. Abbreviations: ANU-ADRI Australian National University Alzheimer’s Disease Risk Index, EV-GRS Explained variance-weighted genetic risk score, SDMT Symbol Digit Modalities Test, MCI Mild cognitive impairment, MCI-TB Test-based mild cognitive impairment