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Table 1 Characteristics of Personality and Total Health Through Life project cohort for waves 1–4

From: Validating the role of the Australian National University Alzheimer’s Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years

  Wave 1, estimate ± SD Wave 2, estimate ± SD Wave 3, estimate ± SD Wave 4, estimate ± SD
n 2078 1798 1596 1337
Age, years 63 ± 1.5 67 ± 1.5 71 ± 1.5 75 ± 1.5
Female sex, n (%) 1009 (48.5) 870 (48.3) 775 (48.6) 651 (48.7)
Education 14 ± 2.8
 Wave 1 completers 12.7 ± 3.0
 Wave 2 completers 13.1 ± 2.7
 Wave 3 completers 13.5 ± 2.7
 Wave 4 completers 14.2 ± 2.6
Immediate recall 7.2 ± 2.3 7 ± 2.2 6.7 ± 2.2 5.4 ± 1.9
Digit Span Backward 4.9 ± 2.2 5.1 ± 2.2 5.1 ± 2.2 5.3 ± 2.2
Spot-the-Word test 52.0 ± 6.0 53 ± 5.3 53 ± 5.1 54 ± 5
SDMT 50.0 ± 9.7 50 ± 9.2 48 ± 9.2 46 ± 9.5
ANU-ADRI 9.4 ± 5.9
EV-GRS 1.6 ± 0.4
Cognitive status, n (%)
 MCI 23 (1.1) 28 (1.6) 35 (2.2) 103 (7.7)
 Dementia 0 (0) 0 (0) 7 (0.44) 37 (2.7)
 MCI-TB 384 (18.4) 373 (20.7) 347 (21.7) 261 (19.5)
Attrition, n (%)
 Death 57 (2.7) 54 (2.5) 94 (5.8)
 Dropout 280 (13.5) 167 (9.3) 329 (20.6)
  1. Abbreviations: ANU-ADRI Australian National University Alzheimer’s Disease Risk Index, EV-GRS Explained variance-weighted genetic risk score, SDMT Symbol Digit Modalities Test, MCI Mild cognitive impairment, MCI-TB Test-based mild cognitive impairment