| |
Wave 1, estimate ± SD
|
Wave 2, estimate ± SD
|
Wave 3, estimate ± SD
|
Wave 4, estimate ± SD
|
|---|
|
n
|
2078
|
1798
|
1596
|
1337
|
|
Age, years
|
63 ± 1.5
|
67 ± 1.5
|
71 ± 1.5
|
75 ± 1.5
|
|
Female sex, n (%)
|
1009 (48.5)
|
870 (48.3)
|
775 (48.6)
|
651 (48.7)
|
|
Education
|
14 ± 2.8
|
–
|
–
|
–
|
|
Wave 1 completers
|
12.7 ± 3.0
|
–
|
–
|
–
|
|
Wave 2 completers
|
13.1 ± 2.7
|
–
|
–
|
–
|
|
Wave 3 completers
|
13.5 ± 2.7
|
–
|
–
|
–
|
|
Wave 4 completers
|
14.2 ± 2.6
|
–
|
–
|
–
|
|
Immediate recall
|
7.2 ± 2.3
|
7 ± 2.2
|
6.7 ± 2.2
|
5.4 ± 1.9
|
|
Digit Span Backward
|
4.9 ± 2.2
|
5.1 ± 2.2
|
5.1 ± 2.2
|
5.3 ± 2.2
|
|
Spot-the-Word test
|
52.0 ± 6.0
|
53 ± 5.3
|
53 ± 5.1
|
54 ± 5
|
|
SDMT
|
50.0 ± 9.7
|
50 ± 9.2
|
48 ± 9.2
|
46 ± 9.5
|
|
ANU-ADRI
|
9.4 ± 5.9
|
–
|
–
|
–
|
|
EV-GRS
|
1.6 ± 0.4
|
–
|
–
|
–
|
|
Cognitive status, n (%)
|
|
MCI
|
23 (1.1)
|
28 (1.6)
|
35 (2.2)
|
103 (7.7)
|
|
Dementia
|
0 (0)
|
0 (0)
|
7 (0.44)
|
37 (2.7)
|
|
MCI-TB
|
384 (18.4)
|
373 (20.7)
|
347 (21.7)
|
261 (19.5)
|
|
Attrition, n (%)
|
|
Death
|
–
|
57 (2.7)
|
54 (2.5)
|
94 (5.8)
|
|
Dropout
|
–
|
280 (13.5)
|
167 (9.3)
|
329 (20.6)
|
-
Abbreviations: ANU-ADRI Australian National University Alzheimer’s Disease Risk Index, EV-GRS Explained variance-weighted genetic risk score, SDMT Symbol Digit Modalities Test, MCI Mild cognitive impairment, MCI-TB Test-based mild cognitive impairment
