Increased dementia risk predominantly in diabetes mellitus rather than in hypertension or hyperlipidemia: a population-based cohort study

Table 3 Sensitivity analysis of incident hypertension and incident hyperlipidemia in prediction of dementia

		Event	PYs	Adjusted model
				HR	95% CI	p value^a
Adjusted confounders without heart related diseases and stroke
DM cohort	Both HTN and HPL^b	126	24,637	0.90	0.65–1.24	0.514
	HTN only^b	124	11,533	1.16	0.85–1.59	0.359
	HPL only^b	25	13,785	0.71	0.44–1.15	0.161
	No HTN and HPL	58	12,932	1.00
Non-DM cohort	Both HTN and HPL^b	130	24,367	1.35	1.10–1.66	0.004
	HTN only^b	418	59,711	1.23	1.07–1.42	0.004
	HPL only^b	31	12,468	1.29	0.90–1.87	0.170
	No HTN and HPL	402	217,378	1.00
Age between 40 and 80 years (n = 43,320)
DM cohort	Both HTN and HPL^c	119	22,358	0.86	0.61–1.22	0.396
	HTN only^c	112	10,409	1.12	0.80–1.58	0.513
	HPL only^c	25	10,657	0.75	0.46–1.23	0.255
	No HTN and HPL	48	8709	1.00
Non-DM cohort	Both HTN and HPL^c	127	23,444	1.33	1.07–1.64	0.009
	HTN only^c	356	55,729	1.23	1.06–1.44	0.008
	HPL only^c	28	11,257	1.19	0.81–1.75	0.380
	No HTN and HPL	354	166,275	1.00

CI confidence interval, COPD chronic obstructive pulmonary disease, DM diabetes mellitus, HTN hypertension, HPL hyperlipidemia, HR hazard ratio, PYs person-years
^aTested using Cox proportional hazards regression
^bAdjusted for age, sex, kidney disease, depression, anxiety, alcoholism, chronic obstructive pulmonary disease, obesity, and insurance amount
^cAdjusted for age, sex, coronary heart disease, stroke, kidney disease, atrial fibrillation, depression, anxiety, heart failure, alcoholism, chronic obstructive pulmonary disease, obesity, and insurance amount

ISSN: 1758-9193