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Table 3 Sensitivity analysis of incident hypertension and incident hyperlipidemia in prediction of dementia

From: Increased dementia risk predominantly in diabetes mellitus rather than in hypertension or hyperlipidemia: a population-based cohort study

   Event PYs Adjusted model
   HR 95% CI p valuea
Adjusted confounders without heart related diseases and stroke
DM cohort Both HTN and HPLb 126 24,637 0.90 0.65–1.24 0.514
HTN onlyb 124 11,533 1.16 0.85–1.59 0.359
HPL onlyb 25 13,785 0.71 0.44–1.15 0.161
No HTN and HPL 58 12,932 1.00   
Non-DM cohort Both HTN and HPLb 130 24,367 1.35 1.10–1.66 0.004
HTN onlyb 418 59,711 1.23 1.07–1.42 0.004
HPL onlyb 31 12,468 1.29 0.90–1.87 0.170
No HTN and HPL 402 217,378 1.00   
Age between 40 and 80 years (n = 43,320)
DM cohort Both HTN and HPLc 119 22,358 0.86 0.61–1.22 0.396
HTN onlyc 112 10,409 1.12 0.80–1.58 0.513
HPL onlyc 25 10,657 0.75 0.46–1.23 0.255
No HTN and HPL 48 8709 1.00   
Non-DM cohort Both HTN and HPLc 127 23,444 1.33 1.07–1.64 0.009
HTN onlyc 356 55,729 1.23 1.06–1.44 0.008
HPL onlyc 28 11,257 1.19 0.81–1.75 0.380
No HTN and HPL 354 166,275 1.00   
  1. CI confidence interval, COPD chronic obstructive pulmonary disease, DM diabetes mellitus, HTN hypertension, HPL hyperlipidemia, HR hazard ratio, PYs person-years
  2. aTested using Cox proportional hazards regression
  3. bAdjusted for age, sex, kidney disease, depression, anxiety, alcoholism, chronic obstructive pulmonary disease, obesity, and insurance amount
  4. cAdjusted for age, sex, coronary heart disease, stroke, kidney disease, atrial fibrillation, depression, anxiety, heart failure, alcoholism, chronic obstructive pulmonary disease, obesity, and insurance amount