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Table 2 Incident hypertension and incident hyperlipidemia in prediction of dementia

From: Increased dementia risk predominantly in diabetes mellitus rather than in hypertension or hyperlipidemia: a population-based cohort study

   Event PYs Crude model Adjusted modelb
   HR 95% CI p valuea HR 95% CI p valuea
DM cohort   333 89,101 1.54 1.36–1.74 <0.001 1.47 1.30–1.67 <0.001
  Both HTN and HPL 126 24,637 1.10 0.81–1.51 0.539 0.90 0.66–1.24 0.529
  HTN only 124 11,533 2.35 1.72–3.22 <0.001 1.17 0.85–1.60 0.341
  HPL only 25 13,785 0.40 0.25–0.64 <0.001 0.72 0.45–1.17 0.189
  No HTN and HPL 58 12,932 1.00    1.00   
Non-DM cohort   981 395,250 1.00    1.00   
  Both HTN and HPL 130 24,367 2.79 2.28–3.41 <0.001 1.33 1.09–1.63 0.006
  HTN only 418 59,711 3.70 3.21–4.25 <0.001 1.22 1.05–1.40 0.008
  HPL only 31 12,468 1.31 0.90–1.89 0.154 1.28 0.89–1.85 0.187
  No HTN and HPL 402 217,378 1.00    1.00   
  1. CI confidence interval, COPD chronic obstructive pulmonary disease, DM diabetes mellitus, HTN hypertension, HPL hyperlipidemia, HR hazard ratio, PYs person-years
  2. aTested using Cox proportional hazards regression
  3. bAdjusted for age, sex, coronary heart disease, stroke, kidney disease, atrial fibrillation, depression, anxiety, heart failure, alcoholism, chronic obstructive pulmonary disease, obesity, and insurance amount