Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

Table 1 Demographics and descriptive statistics

		Control	Cognitive impairment	Statistical test	P
		(n = 44)	(n = 66)	Statistical test	P
Gender	Males	14 (31.8%)	30 (45.5%)	Chi-square	0.155
Gender	Females	30 (68.2%)	36 (54.5%)	Chi-square	0.155
Age	Mean	66	74	t	<0.001
Age	SD	6.57	6.54	t	<0.001
Education level	≤9 years	3 (6.8%)	11 (16.7%)	Chi-square	0.113
	10–12 years	22 (50.0%)	34 (51.5%)
	>12 years	19 (43.2%)	21 (31.8%)
CDR SoB	Mean	0.23	1.96	t	<0.001
CDR SoB	SD	0.1	2.16	t	<0.001
HAD Depression score	Mean	3.79	4.18	t	0.55
HAD Depression score	SD	3.56	3.06	t	0.55
HAD Anxiety score	Mean	6.79	6.45	t	0.65
HAD Anxiety score	SD	4.24	3.2	t	0.65
QPC score	Mean	1.56	2.54	t	<0.01
QPC score	SD	1.5	1.89	t	<0.01
IQCODE score	Mean	3.067	3.467	t	<0.001
IQCODE score	SD	0.42	0.54	t	<0.001
APOEε4 carriers	No	36 (81.8%)	36 (54.5%)	Chi-square	<0.01
APOEε4 carriers	Yes	8 (18.2%)	29 (43.9%)	Chi-square	<0.01
Aβ_1–42 pg/ml	Median	1053	668.75	U	<0.001
Aβ_1–42 pg/ml	IQR	289.6	357.8	U	<0.001
tau pg/ml	Median	209.3	394.35	U	<0.001
tau pg/ml	IQR	115.4	361.3	U	<0.001
ptau-181 pg/ml	Median	46.5	62.3	U	<0.001
ptau-181 pg/ml	IQR	25.2	44.5	U	<0.001
tau/Aβ_1–42 pg/ml	Median	0.219	0.554	U	<0.001
tau/Aβ_1–42 pg/ml	IQR	0.115	0.765	U	<0.001
ptau-181/Aβ_1–42 pg/ml	Median	0.047	0.101	U	<0.001
ptau-181/Aβ_1–42 pg/ml	IQR	0.02	0.097	U	<0.001

CDR SoB Clinical Dementia Rating Sum of Boxes score, HAD Hospital Anxiety and Depression Scale, APOEε4 epsilon 4 allele of Apolipoprotein E, QPC cognitive complaints questionnaire, IQCODE Informant Questionnaire on Cognitive Decline in the Elderly, Aβ amyloid beta, ptau phosphorylated tau, SD standard deviation, IQR interquartile range, U, Mann–Whitney U statistic

ISSN: 1758-9193