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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: The effects of different familial Alzheimer’s disease mutations on APP processing in vivo

Fig. 3

APPswe: correlations between years to onset and Aβ species. Pearson correlations between the Aβ isoforms Aβ38, Aβ40 and Aβ42 and years to expected onset of the first clinically relevant symptoms of FAD in carriers of the APPswe mutation. X axis, −10 represents an individual with 10 years left to the expected onset (which is set to 0) while 10 represents an individual 10 years past the expected onset. All three correlations were significant, Aβ38 (r = −0.69, p = 0.04), Aβ40 (r = −0.67, p = 0.05) and Aβ42 (r = −0.86, p < 0.01), decreasing in subjects sampled closer to the expected onset. amyloid beta

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