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Table 4 Cox proportional HRs (95% CIs) for clinical progression to Alzheimer’s disease-type dementia in nondemented subjects

From: Unbiased estimates of cerebrospinal fluid β-amyloid 1–42 cutoffs in a large memory clinic population

CSF Aβ42 cutoff HR (95% CI) Log-likelihood ratio χ2
<550 pg/ml 5.14 (2.96–8.93)a −327.85 n.a.
<615 pg/ml 7.44 (3.74–14.79)a −324.66 6.38b
  1. Analyses were adjusted for age and sex. Data are from the subsample of nondemented sample with at least 6 months follow-up available seen between 2001 and 2007. The event rate was 33%, and about 13% of subjects were lost to follow up per year
  2. Abbreviations: CSF Cerebrospinal fluid, 42 β-Amyloid 1–42, n.a. Not applicable
  3. a p = 0.0001
  4. bDecrease in χ2 p < 0.01