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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1

Fig. 1

Altered levels of sorting nexin-4 (SNX4) in the brains of patients with Alzheimer’s disease (AD) and APP/PS1 mice. a Expression of SNX4 in the hippocampus of wild-type (WT) (n = 5) and APP/PS1 (n = 5) mice aged 6 months (6 M) and 24 months (24 M) analyzed by Western blotting with antibodies against SNX4, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), β-amyloid (Aβ), and β-actin. Representative images and graphs are shown. Data are presented as mean ± SEM. **p < 0.01, ***p < 0.001. n.s Not significant b Expression of SNX4 in the cortex of WT (n = 5) and APP/PS1 (n = 5) mice aged 6 months and 24 months analyzed by Western blotting with antibodies against SNX4, BACE1, Aβ, and β-actin. Representative images and graphs are shown. Data are presented as mean ± SEM. **p < 0.01, ***p < 0.001. c Expression of SNX4 in AD (n = 8) and non-AD (n = 7) brains analyzed by Western blotting with antibodies against SNX4, BACE1, Aβ, and β-actin. Representative images and graphs are shown. Data are presented as mean ± SEM. **p < 0.01, ***p < 0.001

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