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Table 3 Correlations between regional glucose metabolism, gray matter volume and plasma apoE concentrations

From: Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

apoE4/E3 ratio negative association

Brain region

Coordinates (X, Y, Z)

p value

CMRgl

Hippocampus_R

26, –12, –12

2.49 × 10–4 a

GMV

Cingulate_Post

4, –40, 21

5.60 × 10–4 b

 

Hippocampus_L

–16, –34, 9

4.91 × 10–3

 

Lateral Temporal_L

–48, –64, –3

2.81 × 10–3

 

Lateral Temporal_R

60, –31, 13

1.83 × 10–4

 

Medial Temporal_L

–16, –34, 9

4.91 × 10–3

 

Precuneus_R

8, –43, 18

1.87 × 10–3

  1. a Survived correction at a 0.05 level
  2. b Survived correction at a 0.059 level
  3. CMRgl cerebral metabolic rate of glucose, GMV gray matter volume