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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: Tau passive immunization inhibits not only tau but also Aβ pathology

Fig. 7

Effect of immunization with 43D and 77E9 antibodies on tau pathology lasts several weeks after the last treatment. a Representative Western blots of forebrain developed with R134d against total tau and with several phosphorylation-dependent and site-specific tau antibodies. b Densitometric quantification of phosphorylated tau after normalization with total tau (R134d). c Western blots of forebrain developed with antibodies to apoptotic marker cleaved caspase-3 and neuronal marker NeuN. d Quantification of cleaved caspase-3 and NeuN from (c). n = 5 for WT mice treated with IgG, 43D, and 77E9, and 3×Tg-AD mice treated with 43D + 77E9; n = 6 for 3×Tg-AD mice treated with IgG, 43D, and 77E9. Data are percentages of mouse IgG (100%)-treated animals, reported as mean ± SEM. *p < 0.05, **p < 0.01 by one-way ANOVA followed by Bonferroni post hoc test. AD Alzheimer’s disease, ANOVA Analysis of variance, Amyloid-β, GAPDH Glyceraldehyde 3-phosphate dehydrogenase, IgG Immunoglobulin G, pS199 Phospho-tau (Ser199), pT205 Phospho-tau (Thr205), 3×Tg Triple-transgenic, WT Wild type

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