A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1–42 peptide in human plasma with utility for studies of Alzheimer’s disease therapeutics

Table 9 Summary of measured amyloid-β 1–42 peptide concentrations for samples from study I4O-MC-BACB (n = 36) using both Quanterix and Fujirebio amyloid-β 1–42 peptides for calibration

		Aβ_1–42 (pg/ml)
		Quanterix Aβ_1–42 peptide calibration					Fujirebio Aβ_1–42 peptide calibration
Subject	Dose	Predose	Day 2	Day 4	Day 8	Day 12	Predose	Day 2	Day 4	Day 8	Day 12
R	5 mg		11.9	14.5	13.2	12.2		26.7	32.6	29.7	27.4
S	5 mg		13.2	13.4	12.5	12.5		29.7	30.2	28.1	28.0
T	5 mg	23.6		14.4	13.8	13.2	53.2		32.5	31.2	29.8
L	15 mg	19.0		9.98	8.43	8.24	42.7		22.4	18.9	18.4
M	15 mg	16.9		12.5	9.96	7.22	38.2		28.2	22.3	16.1
N	15 mg	19.7		13.7	10.5	9.52	44.4		30.9	23.7	21.3
O	35 mg	17.6		3.33	4.35	1.65	39.5		7.19	9.54	3.22
P	35 mg	28.3		6.58	4.33	7.70	63.5		14.6	9.48	17.2
Q	35 mg		8.37	4.88	6.15	7.61		18.7	10.8	13.7	17.0

ISSN: 1758-9193